MAGNETIC RESONANCE SPECTROSCOPY IN ATAXIAS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 共济失调是主要影响小脑的神经退行性疾病家族。共济失调的症状包括言语不清、协调困难和平衡问题。在这个项目中，我们将利用在体内，局部磁共振波谱（MRS）在4特斯拉测量共济失调患者小脑的神经化学谱的异常。将在患有不同亚型共济失调的患者以及没有神经系统疾病的健康志愿者中采集质子MR谱。然后将光谱解卷积以获得10-12种神经化学物质的浓度，包括神经递质（谷氨酸盐，GABA，天冬氨酸盐）和抗氧化剂（谷胱甘肽）。将寻求这些标志物水平与共济失调亚型以及疾病分期之间的相关性。这些标记物可用于衡量疾病进展和对未来治疗的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ataxias are a family of neurodegenerative diseases that primarily affect the cerebellum. Symptoms of ataxias include slurred speech, difficulty with coordination, and balance problems. In this project we will utilize in vivo, localized magnetic resonance spectroscopy (MRS) at 4 tesla to measure abnormalities in the neurochemical profile of the cerebellum of patients with ataxia. Proton MR spectra will be acquired in patients with different subtypes of ataxia, as well as in healthy volunteers with no neurological conditions. The spectra will then be deconvoluted to obtain concentrations of 10-12 neurochemicals, including neurotransmitters (glutamate, GABA, aspartate) and antioxidants (glutathione). Correlations between levels of these markers and subtypes of ataxias, as well as disease stage, will be sought. Such markers can be used in gauging disease progression and response to treatment in the future.