TAP03071 - SUB-STUDY OF ENROLLMENT OF NORMAL CONTROL SUBJECTS FOR RESEARCH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 正常对照的使用是各种生物医学研究的关键要求。 组织捐献计划（TDP）已经制定了一项方案（TAP 0307），以登记愿意参加研究的正常受试者队列。TAP 0307包括收集这些受试者的有限数量的人口统计学和临床数据，以及收集和储存唾液/漱口水样本的DNA。我们现在提出一项次级议定书，其目的如下。 该子研究（TAP0307.1）的具体目的是根据三种特定基因之一存在正常遗传变异来识别和招募对照受试者。我们将确定已在TAP 0307中注册的受试者，他们携带三种感兴趣基因的常见变异：MIF、MMP-1和PTPN 22。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of normal controls is a critical requirement for a wide variety of biomedical research. The Tissue Donation Program (TDP) has already established a protocol (TAP0307) in order to register a cohort of normal subjects who are willing to participate in research studies. TAP0307 includes the collection of a limited amount of demographic and clinical data on these subjects, as well as the collection and storage of DNA derived from saliva/mouthwash samples. We are now proposing a sub-protocol with the following aim. The specific aim of this sub-study (TAP0307.1) is to identify and recruit control subjects based on the presence of normal genetic variation in one of three specific genes. We will identify subjects already registered in TAP0307 who carry common variants in three genes of interest: MIF, MMP-1 and PTPN22.