COCRYSTALLIZATION STUDIES OF MEDICALLY RELEVANT PROTEINS WITH SMALL MOLECULE INH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将检查两个不同的治疗目标。第一个是人11βHSD-1与安进配体的络合。HSD-1代表羟基类固醇脱氢酶1，参与脂肪组织中皮质醇水平的调节，可能是脂肪代谢的重要调节因子。第二个蛋白质-配体复合体将是MK2。MK2参与了炎症的调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will be examining two different therapeutic targets. The first is human 11 beta HSD-1 complexed to Amgen ligands. HSD-1 stands for hydroxy steroid dehygrogenase 1 and is involved in the regulation of cortisol levels in fat tissues and may be an important regulator of fat metabolism. The second protein-ligand complexes will be MK2. MK2 is involved in the regulation of inflammation.