TASK FORCE FOR OBESITY RESEARCH AT SOUTHWESTERN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 位于达拉斯的UT西南医学中心已经组建了四个小组，专注于美国的一个主要医学问题--肥胖和代谢综合征。该项目建立了一种机制，将不同的研究人员聚集在一起，调查导致肥胖和代谢综合征的行为，代谢和分子事件。这项工作的主要重点将放在大脑和肝脏上，这两个器官在肥胖的发展及其不良代谢后果中发挥着核心作用。我们的目标是更好地了解大脑如何调节食物摄入和能量消耗，并揭示肝脏中葡萄糖和脂质代谢的失调如何促进代谢综合征的发展。为了实现这些目标，我们开发了四个研究团队，他们在方法和专业知识方面各不相同，将广泛互动，以实现本项目的共同目标。调查人员之间的合作将在两个层面上进行。在每个小组内，调查人员之间的广泛交流将促进直接的协作努力。四个主要小组之间也将进行互动，以利用四个小组各自的不同专门知识，并为我们的主要目标提供全面的方法。这四支队伍是：第一组：能量代谢的中央调节器（首席研究员，基思帕克）;第2小组：能量代谢的分子生物学（首席研究员，杰伊D。霍顿）;第三组：体内中间代谢（首席研究员，克雷格马洛伊）和团队4：人类遗传学和能量代谢（首席研究员，斯科特格伦迪）。在接下来的三年里，主要目标将是：1）制定一项计划，以促进UT西南部的跨学科互动，研究肥胖和代谢综合征; 2）制定一项最先进的计划，以阐明肥胖和代谢综合征的代谢和分子基础使用转基因小鼠;和3）支持在动物模型中取得的科学发现翻译给人类。 本研究使用了人类血浆样本的2 H和13 C NMR研究资源。 在此将其归类为服务项目，因为光谱仪的实际使用由Jeff布朗宁博士指导。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UT Southwestern Medical Center at Dallas has assembled four teams to focus on a major medical problem in the U.S. - obesity and the metabolic syndrome. This project has created mechanisms to bring together diverse groups of investigators to investigate the behavioral, metabolic, and molecular events that cause obesity and the metabolic syndrome. The major focus of this effort will be on the brain and liver, organs that both play central roles in the development of obesity and its adverse metabolic consequences. Our goals are to better understand how the brain regulates food intake and energy expenditure and to reveal how dysregulation of glucose and lipid metabolism in the liver contributes to the development of the metabolic syndrome. To address these objectives, we have developed four research teams that vary in approaches and expertise that will interact extensively to pursue the shared goals of this project. Collaborations among investigators will occur on two levels. Within each team, extensive exchanges between investigators will foster direct collaborative efforts. Interactions will also occur between the four major teams to capitalize on the diverse expertise within each of the four groups and to provide comprehensive approaches to our major objectives. These four teams are: Team 1: Central Regulators of Energy Metabolism (Lead Investigator, Keith Parker); Team 2: Molecular Biology of Energy Metabolism (Lead Investigator, Jay D. Horton); Team 3: In Vivo Intermediary Metabolism (Lead Investigator, Craig Malloy) and Team 4: Human Genetics and Energy Metabolism (Lead Investigator, Scott Grundy). Over the next three years, the major objectives will be to: 1) develop a program to foster interdisciplinary interactions at UT Southwestern to study obesity and the metabolic syndrome; 2) develop a state-of-the-art program to elucidate the metabolic and molecular basis of obesity and the metabolic syndrome using genetically modified mice; and 3) support the translation of scientific findings made in animal models to humans. This study uses the Research Resource for the 2H and 13C NMR of plasma samples from humans. It is classified here as a service project because the actual use of the spectrometers is directed by Dr. Jeff Browning.