XENOPUS LINKER PROTEINS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 膜结合的细胞器显示出特征性的空间组织，它们的调节定位和运动是有丝分裂和细胞极化等基本过程的关键。极性的破坏和异常的细胞组织与癌症的发展和进展有关。细胞骨架元件和细胞器之间的连接蛋白对于确定细胞组织是至关重要的。我们正在使用基于非洲爪蟾卵提取物的蛋白质组学方法来识别新的潜在接头。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Membrane-bound organelles show a characteristic spatial organization and their regulated positioning and movement are key to fundamental processes like mitosis and cell polarization. Disruption of polarity and abnormal cellular organization are linked to the development and progression of cancer. Linker proteins between cytoskeletal elements and organelles are critical for determining cellular organization. We are using a Xenopus egg extract-based proteomics approach to identify novel potential linkers.