RESOLUTION LIMITS FOR FLUORESCENCE TOMOGRAPHIC MOLECULAR IMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议进行研究，以确定使用过采样测量的荧光漫反射光学层析成像(F-DOT)的分辨率极限。它将利用NCRR National Resources的两项综合专长：使用杜克大学活体显微镜(CIVM)中心最近建立的分子成像工作台获取数据，以及使用匹兹堡超级计算中心(PSC)的并行计算设施进行图像重建。具体地说，我们将进行以下研究：(I)开发用于F-DOT模拟和图像重建的开放式结构软件包；(Ii)在没有先验信息的情况下研究模体和动物的分辨率极限；以及(Iii)研究同时从Micro-CT获得先验信息来提高分辨率极限。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are proposing studies to determine the resolution limits for fluorescence diffuse optical tomography (F-DOT) using over-sampled measurements. It will exploit the combined expertise of two NCRR National Resources: data acquisition using the recently established molecular imaging workbench at the Duke Center for In Vivo Microscopy (CIVM) and image reconstruction using the parallel computing facilities at the Pittsburgh Supercomputing Center (PSC). Specifically, we will be conducting the following studies: (i) Development of open-structured software package for F-DOT simulations and image reconstruction; (ii) Study of resolution limit in phantoms and animals without prior information; and (iii) Study the improvement of resolution limit with simultaneously acquired prior information from micro-CT.