HIPPO MORPHOMETRY IN FRONTOTEMPORAL DEMENTIA: A RADIAL ATROPHY MAPPING STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：在比较FTD和AD患者的研究中，已经多次检测到类似数量的海马萎缩，但萎缩变化的分布可能不同。最近的技术，如放射状萎缩映射，不仅可以根据萎缩的绝对数量，而且还可以根据其空间分布来表征不同类型痴呆的萎缩变化。 方法：在维罗纳大学放射科收集9例FTD患者和27例对照的MRI图像，使用1.5Tesla装置(西门子，Magnetom)和一个标准的头线圈。采用梯度回波3D技术进行图像采集：TR10毫秒；TE 4毫秒；TI 300毫秒；翻转角度10？；视野250 mm；采集2；矩阵160？256。总采集时间为7：40分钟。 MRI图像将通过使用统计参数映射(SPM99)软件将线性(12个参数)变换为定制模板来归一化。将根据正式协议手动跟踪海马体，并建立评分者之间和内部的可靠性，并将创建3D参数表面网格模型来表示每个受试者的海马体。为了评估海马区的形态，将自动定义一条内侧曲线，即在每个图像切片中由海马区边界的质心描绘出的3D曲线。每个边界点的每个海马体的径向大小将通过自动测量从表面点到为个人海马体表面模型定义的内侧曲线的径向3D距离来评估。较短的放射状距离将被用作萎缩的指标。将生成统计地图，显示放射状海马区距离的局部组差异。 预期结果：实验预测包括检测到海马体最前部的萎缩，这一点已经由一项基于手动追踪的研究(Laakso等人，2000年)提出，或者无论如何，在与AD不同的位置，涉及CA1区和下丘脑的一部分。 Laakso MP，Frisoni GB，Kononen M，Mikkonen M，Beltramello A，Geroldi C，Bianchetti A，Trabuchi M，Soininen H，Aronen HJ。额颞叶痴呆和阿尔茨海默病患者的海马区和内嗅区皮质：形态计量学mri研究。生物精神病学。2000；47：1056-63。 Frisoni GB，Sabattoli F，Lee AD，duton RA，Toga AW，Thompson PM阿尔茨海默病患者海马区的活体神经病理学：一项基于放射状核磁共振成像的研究。神经影像。2006；32(1)：104-10。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background: similar amount of hippocampal atrophy has been repeatedly detected in studies comparing FTD to AD patients, nonetheless the distribution of the atrophic changes may be different. Recent techniques such as radial atrophy mapping allow to characterize the atrophic changes of different kinds of dementia based not only on the absolute quantity of atrophy, but also on its spatial distribution. Methods: MRI images from 9 FTD patients and 27 controls were collected at the Radiology Department, University of Verona with a 1.5 Tesla unit (Siemens, Magnetom) and a standard head coil. A gradient-echo 3D-technique was employed for image acquisition with: TR 10 msec; TE 4 msec; TI 300 msec; flip angle 10?; field of view 250 mm; acquisition 2; matrix 160?256. Total acquisition time was 7:40 minutes. MRI images will be normalized by linear (12 parameter) transformation to a customized template using the Statistical Parametric Mapping (SPM99) software. The hippocampi will be manually traced according to a formal protocol with established inter- and intra-rater reliability and 3D parametric surface mesh models will be created to represent the hippocampus in each subject. In order to assess hippocampal morphology, a medial curve will be automatically defined as the 3D curve traced out by the centroid of the hippocampal boundary in each image slice. The radial size of each hippocampus at each boundary point will be assessed by automatically measuring the radial 3D distance from the surface points to the medial curve defined for individual's hippocampal surface model. Shorter radial distances will be used as an index of atrophy. Statistical maps will be generated indicating local group differences in radial hippocampal distance. Expected results: the experimental prediction consists in the detection of atrophy in the anteriormost sectors of the hippocampus, as already suggested by a study based on manual tracings (Laakso et al., 2000) or anyway in a different location from that of AD, that involves the CA1 sector and part of the subiculum. Laakso MP, Frisoni GB, Kononen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study. Biol Psychiatry. 2000;47:1056-63. Frisoni GB, Sabattoli F, Lee AD, Dutton RA, Toga AW, Thompson PM. In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage. 2006; 32(1):104-10.