INBRE: WINTHROP U: FACULTY & UNDERGRADUATE RESEARCH DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 温斯罗普大学认识到改善南卡罗来纳州公民健康的迫切需要，并作为该州第二大公共卫生机构，提议建立一个独特的生物医学研究项目，专注于主要的人类健康问题。在接下来的五年里，温斯罗普将投资170万美元的自有资金来实现这一目标。温斯罗普提出了六个研究项目，重点是：1)检测心脏组织损伤的修复机制，2)研究前列腺癌中调节血管生成和细胞运动的潜在机制，3)开发新的光谱工具，以更好地了解生命系统中金属和分子之间的广泛特定相互作用，4)完成最近参与肥胖发展的蛋白质的结构分析，5)通过确定对这些过程至关重要的分子区域来揭示致癌蛋白质在癌症进展中扮演的特定角色，以及6)使用生物信息学技术来预测乙肝病毒的进化路径。这六个项目将得到以下支持：1)生物医学核心实验室设施，其中包括4个新的科学家工作人员职位；2)有针对性的指导，以提供援助、建议和资源，以实现个别项目目标。温斯罗普的分子生物医学为学生提供了一个多学科的视角，支持和跨越了南卡罗来纳州再生医学努力的范围。在对人类疾病过程的分子理解方面的进展为在解决影响人类健康的关键问题方面取得重大进展提供了潜力。温斯罗普的重点是在项目之间提供巨大的重叠，为培养学生提供一个多学科的环境，并协同发展一个强大的实验室核心。温斯罗普计划的具体目标是：1)显著扩大生物医学研究能力，2)提高教师对外部生物医学研究资金的竞争力，3)建立强大的生物医学研究基础设施支持核心，4)通过建立综合的化学-生物生物医学科学课程，为学生提供强大的生物医学科学跨学科基础和生物医学研究经验，5)增加生物和化学毕业生进入生物医学研究领域的数量和比例，以及6)招聘，培训和指导温斯罗普的许多来自代表不足的群体的当前和未来的学生，以增加进入生物医学研究专业的温斯罗普女性和少数族裔毕业生的数量和比例。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recognition of the critical need to improve the health of South Carolina's citizens and as the State's second largest PUI, Winthrop University proposes to establish a distinctive biomedical research program to focus on major human health concerns. Over the next five years, Winthrop will invest $1.7 million of its own funds to accomplish this goal. Winthrop proposes six research projects focusing on: 1) examining repair mechanisms for cardiac tissue damage, 2) investigating potential mechanisms that regulate angiogenesis and cell motility in prostate cancer, 3) developing new spectroscopic tools to better understand a wide range of specific interactions between metals and molecules in living systems, 4) completing the structural analysis of a protein recently implicated in obesity development, 5) revealing the specific role that oncogenic proteins play in cancer progression by identifying the molecular regions that are critical to these processes, and 6) using bioinformatic techniques to project evolutionary pathways of the Hepatitis B virus. These six projects will be supported by: 1) a biomedical core laboratory facility that includes four new staff scientist positions, and 2) targeted mentorship to provide assistance, advice, and resources to meet individual project goals. Winthrop's molecular biomedical focus provides students with a multidisciplinary perspective that underpins and spans the range of South Carolina's regenerative medicine efforts. Advances in a molecular understanding of human disease processes provide the potential for significant progress in addressing critical problems affecting human health. Winthrop's focus provides tremendous overlap among projects, a multidisciplinary environment for training of students, and the synergistic development of a strong lab core. The specific objectives of Winthrop's program are to: 1) dramatically expand biomedical research capacity, 2) increase the competitiveness of faculty for external biomedical research funding, 3) establish a strong biomedical research infrastructure support core, 4) provide students with a strong interdisciplinary foundation in the biomedical sciences and with experience in biomedical research through the establishment of an integrated chemistry-biology biomedical science curriculum, 5) increase the number and the percentage of biology and chemistry graduates that enter biomedical research fields, and 6) recruit, train and mentor Winthrop's many current and future students from underrepresented groups to increase the number and the percentage of Winthrop female and minority graduates that enter the biomedical research profession.