Pediatric Clinical Oncology Research Training Program

描述（由申请人提供）：本提案构成了由贝勒医学院德克萨斯儿童癌症中心开发的儿科肿瘤学临床研究培训计划（POCRTP）的更新申请。该培训计划的前提是，在临床研究中训练有素的儿科肿瘤学家和儿科肿瘤护士的发展对于儿童癌症治疗的持续进展至关重要。这一更新申请突出了在过去五年中招募的个别学员令人印象深刻的学术成就和进步。该计划的结构是提供一个正式的，全面的，多学科的临床研究教育计划，培训（1）儿科医生谁已经完成了为期三年的儿科血液学-肿瘤学奖学金培训计划，并在该子专业的董事会资格，（2）博士。对儿科肿瘤临床研究感兴趣的护士。在这一“单轨”计划中，被指定为“Paul Calabresi学者”的学员将接受全面的教学培训，并在临床研究试验的设计、实施、开展和分析方面获得指导培训经验。该计划强调在团队研究环境中进行治疗研究的培训，其中基础和临床科学家相互作用，以加快将基础研究发现转化为以患者为导向的治疗性癌症研究。该计划包括参与临床研究和试验设计的核心教学课程，通过贝勒医学院的临床科学家培训计划提供，以及深入的临床研究培训经验，重点是五个专业研究领域之一，指定为“途径”，由受训者选择。POCRTP途径包括临床药理学、神经肿瘤学、细胞和基因治疗、白血病或实体瘤。每一个路径的研究经验是专为满足个别学员的长期研究目标.所有学员都接受实验室研究和临床研究导师的全面指导，并接受临床试验设计，统计分析，研究伦理和监管要求和指南的深入指导。此外，学员设计并在各自的路径进行临床试验。在此更新期间，增加了国家癌症研究所癌症治疗评估计划的选修轮换。迄今为止的经验表明，完成该计划的学员在临床研究方面受到了非常良好的培训，非常成功地获得了NIH的资助，并有能力成为儿科肿瘤临床研究的未来领导者。

DESCRIPTION (provided by applicant): This proposal constitutes the renewal application of the Pediatric Oncology Clinical Research Training Program (POCRTP), developed by Baylor College of Medicine's Texas Children's Cancer Center. This training program is predicated on the premise that the development of pediatric oncologists and pediatric oncology nurses who are highly trained in clinical research is essential for continued progress to be made in the treatment of childhood cancer. This renewal application highlights the impressive academic accomplishments and progress of the individual trainees recruited during the last five years. The program is structured to provide a formal, comprehensive, multidisciplinary clinical research educational program that trains (1) pediatricians who have completed a three-year pediatric hematology-oncology fellowship training program and are board eligible in that subspecialty and, (2) Ph.D. nurses with a career interest in pediatric oncology clinical research. Trainees, in this "one-track" program, designated "Paul Calabresi Scholars", receive comprehensive didactic training and a mentored training experience in the design, implementation, conduct and analysis of clinical research trials. The program emphasizes training in therapeutic research that occurs in team research settings in which basic and clinical scientists interact to expedite the translation of basic research discoveries into patient-oriented therapeutic cancer research. The program includes participation in a core didactic course in clinical investigation and trial design, provided through Baylor College of Medicine's Clinical Scientist Training Program, and an in-depth clinical research training experience focused in one of five specialized research areas, designated "Pathways", chosen by the trainee. The POCRTP Pathways include clinical pharmacology, neuro-oncology, cell and gene therapy, leukemia or solid tumors. The research experience within each Pathway is tailored to meet the individual trainee's long- term research goals. All trainees receive comprehensive mentorship by both a laboratory research and a clinical research mentor and receive in depth instruction in clinical trial design, statistical analysis, research ethics and regulatory requirements and guidelines. In addition, trainees design and conduct clinical trials in their respective Pathways. In this renewal period, an elective rotation at the National Cancer Institute's Cancer Therapy Evaluation Program has been added. The experience to date indicates that trainees who complete this program are exceptionally well trained in clinical research, very successful in obtaining NIH funding and well positioned to become future leaders in pediatric oncology clinical research.