OBESITY, DECREASED FERTILITY, AND LEPTIN RESISTANCE IN THE LETHAL YELLOW MOUSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们研究的总体目标是使用致命的黄色小鼠模型来了解人类和其他哺乳动物中肥胖增加和生育能力下降之间的关系。我们目前正在研究激素瘦素在卵巢功能和卵母细胞发育中的作用，以及瘦素抵抗对卵泡发育、卵母细胞成熟和胚胎活力的不利影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of our research is to understand the relationship between increasing obesity and decreasing fertility in humans and other mammals using the lethal yellow mouse model. We are currently working on the role of the hormone leptin in ovarian function and oocyte development and the adverse effects of leptin resistance on follicle development, oocyte maturation, and embryo viability.