International

自1997年以来，国际核心(1C)一直是联合航空公司CFAR的主要组成部分。随着CFAR和1C的变化 在领导这最后一个项目期间，1C已经尖锐地聚焦于赞比亚和取得的显著成就 在那里发生，主要是通过与赞比亚传染病研究中心的直接合作 (CIDRZ)。CFAR在20世纪90年代末帮助建立了CIDRZ，其使命是为艾滋病毒提供基础设施支持 赞比亚的相关研究和治疗计划。在过去的资助期内，CFAR使CIDRZ能够 创建高通量临床实验室检测能力，高质量流式细胞仪准确检测CD4 检测、病毒载量测试、结核病培养和快速诊断技术，以及对艾滋病毒的抵抗能力。这个 CFAR发挥的最重要作用是创建支持推广的临床护理方案和基础设施 通过CIDRZ和赞比亚卫生部实施的PEPFAR项目。使用这一非凡的系统，PEPFAR 卢萨卡的项目目前在46个社区诊所运作，评估了超过16.5万名艾滋病毒感染患者， 让其中100,000人接受抗逆转录病毒治疗。自1999年以来，CIDRZ团队已经对超过50万名孕妇进行了评估 妇女预防母婴传播，防止数以万计的婴儿感染艾滋病毒 被感染了。CFAR帮助创建了适当的基础设施，以支持DAIDS赞助的网络临床试验和 标本库，用于支持卢萨卡的临床-翻译研究，帮助建立 赞比亚和UAB调查人员之间的双向研究和培训机会。《公约》的具体目标 下一个项目期的1C是： 1)进一步发展CFAR/CIDRZ标本储存库，以便向调查人员提供患者样本 高质量的研究想法，重点放在与赞比亚最相关的项目上； 2)进一步开发CFAR/CIDRZ数据库，以提供分析数据集和分析支持 调查员以高质量的研究思路，特别关注初级调查员和赞比亚人 调查员； 3)为伯明翰的CFAR成员提供临床和基础科学研究方面的双向培训，并 赞比亚调查人员； 4)通过支持为CIDRZ和CFAR在赞比亚的其他合作者提供领导和战略规划 CIDRZ科学咨询委员会主席。 衡量1C成功的标准将是启动和支持的新项目数量、新项目的数量 提交的赠款提案，包括开发性赠款提案、正在进行的项目的出版物数量、 核心培训的赞比亚新调查员的人数和他们的生产力，以及其他 UAB小组或中心到整个1C努力。

The International Core (1C) has been a major element of the UAB CFAR since 1997. With the change in CFAR and 1C leadership in this last project period, the 1C has sharply focused on Zambia and the remarkable achievements occurring there, principally through a direct partnership with the Center for Infectious Diseases Research in Zambia (CIDRZ). The CFAR helped establish CIDRZ in the late 1990s with a mission to provide infrastructure support for HIV related research and treatment programs in Zambia. Over the last funding period, the CFAR has enabled CIDRZ to create laboratory capacity in high-through put clinical laboratory testing, high quality flow cytometry for accurate CD4 determinations, viral load testing, TB culture and rapid diagnostic techniques, and HIV resistance capabilities. The most important role CFAR has played is in creating the clinical care protocols and infrastructure to support the rollout of the PEPFAR program via CIDRZ and the Zambian Ministry of Health. Using this remarkable system, the PEPFAR program in Lusaka now operates in 46 community clinics and has evaluated over 165,000 HIV infected patients, placing over 100,000 of them on ARV treatment. The CIDRZ team, since 1999, has evaluated over 500,000 pregnant women for prevention of mother-to-child transmission and prevented tens of thousands of infants from becoming HIV infected. The CFAR helped create the proper infrastructure to support DAIDS-sponsored Network clinical trials and a specimen repository that is used to support the clinical-translational studies in Lusaka, helping to establish bidirectional research and training opportunities between Zambian and UAB investigators. The Specific Aims of the 1C for this next project period are: 1) To develop further the CFAR/CIDRZ specimen repository in order to provide patient samples to investigators with high-quality research ideas, with a focus on projects most relevant to Zambia; 2) To develop further the CFAR/CIDRZ data repository in order to provide analysis datasets and analytic support to investigators with high-quality research ideas, paying special attention to junior investigators and Zambian investigators; 3) To provide bidirectional training in clinical and basic science research for Birmingham-based CFAR Members and Zambian Investigators; 4) To provide leadership and strategic planning for CIDRZ and other CFAR collaborators in Zambia through support of the CIDRZ Scientific Advisory Committee. The measures for success for the 1C will be the number of new programs initiated and supported, numbers of new grant proposals submitted including Developmental Grant proposals, numbers of publications from ongoing projects, the number of new Zambian investigators trained by the Core and their productivity, and the contributions by other UAB groups or centers to the overall 1C effort.