CELLULAR, MOLECULAR, HISTOPHATOL, AND PHYSIOL CHAR OF A MACAQUE MODEL OF COPD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该研究的主要目的是通过治疗两组猴子来开发人类疾病的恒河猴COPD模型：一组暴露于DCS和VEGF抑制剂，另一组暴露于临床相关水平的DCS和呼吸道感染。 将经治疗的COPD猴与健康对照进行比较。 上述研究应允许： 1. 恒河猴中COPD反应的诱导和随后随时间发展的表征。 2 使用细胞、分子和组织病理学技术，以确认先前在人类疾病组织中的发现（模型验证），以及鉴定先前与COPD无关的生物标志物和/或药物靶点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main aim of the study is to develop a rhesus monkey COPD model of human disease by treating two groups of monkeys: one group is exposed to DCS and a VEGF inhibitor, and the other group is exposed to clinically relevant levels of DCS and a respiratory infection. Treated COPD monkeys are compared to healthy controls. The above study should permit: 1. Characterization of the induction and subsequent development over time of the COPD response in rhesus monkeys. 2 Use of using cellular, molecular, and histopathological techniques, to confirm previous findings in human disease tissues (validation of model), as well as identify biomarkers and/or drug targets not previously associated with COPD.