RHESUS CMV INFECTION OF IMMUNOSUPPRESSED CMV NATIVE RHESUS MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一试点项目旨在评估免疫抑制条件下恒河猴巨细胞病毒(RhCMV)的参数，以反映人类移植受者的免疫抑制状态。这项研究的目的是表征免疫抑制猕猴TO中的RhCMV复制动力学，作为后续研究的必要前提，这些研究将评估在免疫抑制期间防止RhCMV复制的疫苗方案，如HIV。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot project is designed to evaluate the parameters of rhesus cytomegalovirus (RhCMV) under immunosuppressive conditions that reflect the state of immunosuppression in human transplant recipients. The goal of this study is to characterize the kinetics of RhCMV replication in immunosuppressed macaques to as a necessary prerequisite to subsequent studies that will evaluate vaccine regimens that would prevent RhCMV replication during immunosuppression such as HIV.