ACUTE SIV INFECTION: BONE MARROW MONOCYTE OUTPUT AND VIRUS IMPORT INTO THE CNS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议的研究的总体目标是在获得性免疫缺陷病毒综合征(AIDS)的动物模型中表征单核细胞作为病毒脑进入的“特洛伊木马”的作用。具体目标是检查急性感染期间可能发生的骨髓功能和单核细胞输出的变化，以及单核细胞一旦进入外周血池，如何迁移到中枢神经系统。明确外周血池中新释放的单核细胞的特征及其早期脑渗透的能力可能会导致新的药物靶向和治疗方案，通过靶向特定的单核细胞亚群或其迁移信号来抑制急性和慢性神经炎。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposed study is to characterize the role of monocytes as 'Trojan Horse' for viral brain entry in an animal model for acquired immunodeficiency virus syndrome (AIDS). The specific objective is to examine possible altered bone marrow functions and monocyte output during acute infection and how monocytes, once emerged into the peripheral blood pool, migrate onward into the Central Nervous System. Defining the characteristics of newly released monocytes in the peripheral blood pool and their capacity for early brain infiltration could lead to novel drug targeting and treatment options that inhibit acute and chronic neuroinflammation by targeting specific monocyte subsets or their migratory signals.