A New Method for Determining Gastric Acid Output Using a Wireless Capsule

与酸有关的疾病有很多，通常需要长期治疗和维持。这些疾病中的许多都没有症状，因此很难诊断和治疗。胃液分析是胃酸排出量的定量测量，是诊断胃酸相关疾病和持续评估治疗反应的重要工具。目前，胃分析需要一种技术上困难的程序，即通过鼻胃管进行胃抽吸，这对患者来说是昂贵的、有创的和不舒服的。最近推出了SmartPill，这是一种一次性药片，可以测量整个胃肠道的pH值、温度和压力。我们建议进行一项试验性研究，以验证一种新的胃部分析方法，即通过摄入具有已知缓冲能力的食物来测量胃酸的酸度和胃酸排出量。我们将通过在最大刺激条件下将其与公认的胃抽吸法进行比较来验证该方法。我们将研究健康志愿者的验证阶段，然后研究已知的酸相关疾病患者，以评估其在患者中的有效性。感兴趣的受试者将向NIH门诊胃肠诊所报到进行评估，随后是3天的住院和随后的2次诊所就诊。受试者将用常规方法和研究方法对基础、饮食刺激和药物刺激的比率进行胃部分析。结果将包括定量测量单位时间内的胃酸排出量，健康志愿者和酸相关疾病患者的正常饮食刺激的胃酸排出值，以及评估接受各种抗分泌药物治疗的患者的酸抑制情况。 我们刚刚开始招募患者，因此目前还没有可以报告的成果。

Acid related disorders are numerous and often require chronic treatment and maintenance. Many of these diseases are without symptoms and therefore difficult to diagnose and treat. Gastric analysis is the quantitative measurement of gastric acid output and is a critical tool for the diagnosis of acid related disorders and the ongoing assessment of therapy response. At present gastric analysis requires a technically difficult procedure, using gastric aspiration through a nasogastric tube, that is costly, invasive, and uncomfortable for patients. Recently there is introduction of the SmartPill, which is a disposable pill that measures pH, temperature, and pressure throughout the GI tract. We propose a pilot study to validate a new method of gastric analysis with the ingestion of the SmartPill with a meal of a known buffering capacity to measure both the acidity and quantity of acid output in the stomach. We will validate this method by comparing it to the accepted gastric aspiration method under maximally stimulated conditions. We will study healthy volunteers for the validation phase and then study patients with known acid related disorders to assess its usefulness in patients. Interested subjects will report to the NIH outpatient gastrointestinal clinic for evaluation to be followed by a 3 day in-patient admission and 2 subsequent clinic visits. Subjects will have gastric analysis of basal, meal stimulated, and pharmacologically stimulated rates with both the conventional and study methods. Outcomes will include a quantitative measurement of gastric acid output in unit time, normal meal stimulated acid output values in healthy volunteers and patients with acid related disorders, and the assessment of acid suppression in patients treated with a variety of anti-secretory medications. We have just begun enrolling patients and therefore there are no accomplishments that can be reported at this time.