NIH Chemical Genomics Center

在本报告所述的一年中，NCGC与世界各地的100多名研究人员合作。NCGC与分子文库探针生产中心网络(MLPCN)、美国环境保护局、国家毒理学计划、NIEHS、NCI、众多罕见疾病基金会和其他实验室合作，对几乎对生物学和疾病每个领域都重要的分子靶标和细胞表型进行了60多次高通量筛选。NCGC还扩大了其科学广度，将siRNA领域的新工作包括在内。 发现了12种不同生物的新化学探针，NCGC的科学家在09财年发表了30多份出版物。其中两份是外联出版物，专门用来宣传NCGC和MLPCN的科学知识和成就，并吸引新的调查人员。在本报告所述期间，NCGC提交了4项专利申请。对PubChem数据库进行了61份证词，保持了NCGCs作为所有MLPCN中心中PubChem分析的主要贡献者的地位。NCGC继续将其化学专业知识应用于优化探针；年内实施了23个化学项目。 由于NCGCS的持续效率改进计划，我们能够通过在项目团队和项目管理的推动下，在应用程序、软件和利用调度方面的改进，增加现有机器人筛选、信息学和化学系统(特别是分析化学系统)的吞吐量。在本报告所述期间，NCGC还纳入了新的机器人技术和生物安全2级和3级项目。 在本报告所述期间，NCGCs外联方案继续保持其非凡的生产力记录。NCGC的工作人员就检测设计和检测开发为135名外部研究人员提供建议，并协助20多名研究人员进行化学、信息学和技术开发方面的询问。在此期间，NCGC的科学家们在美国、欧洲和亚洲进行了72次应邀演讲。NCGC的推广活动导致提交了20多份MLPCN项目的化验筛选申请。 NCGC网站(ncgc.nih.gov)得到维护，目前正在完全重新设计，新网站预计将在下一财政年度推出。NCGC网站上的分析指导手册继续发展，已成为对MLPCN科学感兴趣的调查人员的核心资源；该手册的网络点击量远远超过100万次，有来自100多个不同国家的近10万独立访问者。平均每次访问有13次浏览量，表明该网站已成为社区宝贵的资源。 年内，NCGC还成功地与校外中心竞争，成为NCIS新成立的化学生物学联盟的一部分。

During the reporting year, the NCGC worked with over 100 researchers worldwide. In collaboration with the Molecular Libraries Probe Production Centers Network (MLPCN), the U.S. Environmental Protection Agency, the National Toxicology Program, NIEHS, NCI, numerous rare disease foundations, and other laboratories, the NCGC and performed over 60 high-throughput screens on molecular targets and cellular phenotypes important for virtually every area of biology and disease. The NCGC also expanded its scientific breadth to include new work in the field of siRNA. 12 new chemical probes of diverse biologies were discovered, and NCGC scientists published over 30 publications during FY09. Two of these were outreach publications, designed specifically to promulgate knowledge of the science and accomplishments of the NCGC and MLPCN and to attract new investigators. The NCGC filed 4 patent applications during this reporting period. 61 depositions were made to the PubChem database, maintaining NCGCs position as the leading contributor of assays to PubChem out of all MLPCN centers. NCGC continued to apply its chemistry expertise to optimizing probes; 23 chemistry projects were implemented during the year. Given the NCGCs continual efficiency improvement program, we were able to increase the throughput of existing robotic screening, informatics, and chemistry systems (particularly analytical chemistry) by improvements in applications, software, and utilization scheduling, driven by both the project teams and Project Management. The NCGC also incorporated new robotic technology and Bio Safety Level 2 and 3 projects during the reporting period. The NCGCs Outreach program continued its extraordinary record of productivity during the reporting period. NCGC staff advised 135 outside investigators on assay design and assay development, and assisted many over 20 investigators with chemistry, informatics, and technology development inquiries. NCGC scientists gave 72 invited presentations throughout the U.S., Europe, and Asia during the period. NCGC outreach resulted in the submission of over 20 assay screening applications for MLPCN programs. The NCGC website (ncgc.nih.gov), was maintained and is currently being completely redesigned, with a new site roll-out expected in the next fiscal year. The Assay Guidance manual on the NCGC website has continued to evolve and has become a central resource for investigators interested in MLPCN science; the manual has received well over 1 million web hits, with nearly 100,000 unique visitors originating from over 100 different countries. On average, there are 13 views per visit, indicating that the site has become a valued resources to the community. During the year, the NCGC also successfully competed with extramural centers to become a part of the NCIs newly formed Chemical Biology Consortium.