Neurobiological and Behavioral Substrates of Mood Disorders

这项申请的主要目的是在“病人”领域获得职业中期研究者奖， “以人为本的研究”（POR）是为了支持先进的专业知识的发展， 神经成像和认知神经科学，以便更精确地检查 病理生理学中情绪、认知和神经元连接之间的关系 情绪障碍一个平行的目标是让申请人阿南德·库马尔继续 指导初级研究人员在POR，无论是在东道国机构，大学 加州、洛杉矶（UCLA）和全国。申请人将使用磁性 共振成像（MRI）相关方法 磁共振波谱（MRS）和扩散张量成像（DTI）来表征和 系统研究白色物质损伤和连接受损在情绪中的作用 紊乱此外，他将获得专业知识，在检查认知相关的 情绪障碍和整合神经心理学和神经影像学措施， 为了全面评估神经回路在病理生理学中的地位， 情绪障碍申请人还将继续花时间指导初级 研究人员在POR，特别是因为它涉及到情绪障碍，在中后期的生活。的 申请人的科学目标，目标和职业轨迹使K24机制 最适合他在学术医学上的进一步成长和发展。

The primary objective of this application for a mid-career investigator award in "patient oriented research" (POR) is to support the development of advanced expertise in neuroimaging and cognitive neuroscience in order to more precisely examine the relationship between mood, cognition and neuronal connectivity in the pathophysiology of mood disorders. A parallel objective is for the applicant, Anand Kumar, to continue to mentor junior investigators in POR, both within the host institution, the University of California, Los Angeles (UCLA) and nationally. The applicant will use magnetic resonance imaging (MRI) related approaches such as magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to characterize and systematically study the role of white matter injury and impaired connectivity in mood disorders. In addition, he will gain expertise in examining the cognitive correlates of mood disorders and integrating neuropsychological and neuroimaging measures in order to comprehensively assess the status of neuronal circuits in the pathophysiology of mood disorders. The applicant will also continue to devote time to mentoring junior investigators in POR especially as it relates to mood disorders in mid-late life. The applicant's scientific goals, objectives and career trajectory make the K24 mechanism optimal for his further growth and development in academic medicine.