A micro-CT scanner for in vivo mouse imaging and ex vivo monkey tissue imaging

描述（由申请人提供）：本申请为购买一台Skyscan 1066微型ct，用于俄勒冈国家灵长类动物研究中心（ONPRC）和俄勒冈健康与科学大学（OHSU）的小鼠体内成像和猴子体外组织成像而申请资金。ONPRC的使命是从基础科学到临床前猴子模型再到临床研究。因此，这种扫描仪既可以对小鼠进行体内扫描，也可以对猴子组织进行体外扫描，非常适合ONPRC的任务。我们评估了来自Skyscan、Scanco、GE和Siemens的微型ct扫描仪。我们选择了Skyscan 1076，因为它在高分辨率（9微米）和最大样品直径（68毫米）方面具有最大的通用性，可用于猴组织的离体扫描，并且具有灵活的分辨率，扫描尺寸和生理控制和门控能力。该扫描仪支持的研究将支持ONPRC的重点研究领域，包括生殖生物学、代谢调控、发育生物学和肿瘤学。该扫描仪还将支持ONPRC主办机构OHSU的心血管研究、肿瘤学和内分泌学研究。将有5个主要用户和6个次要用户。主要用户将集中于不孕、肥胖、肺病和胎盘功能不全，这些都是对人类健康非常重要的领域。该系统的使用将由一位博士生物物理学家指导，他也指导ONPRC MRI核心。一位经验丰富的小动物放射技师将监督日常使用，并负责培训新用户。由用户、地方和国家微型ct专家组成的咨询委员会将协助管理工作，并确保适当的培训和数据分析。强有力的体制支助将提供必要的装修，以安置扫描仪，支付服务合同费用和技术人员和物理学家的人事费用。由于波特兰市没有微型ct扫描仪，该扫描仪将满足主要需求，离波特兰市最近的扫描仪位于俄勒冈州立大学，距离波特兰市两小时车程。

DESCRIPTION (provided by applicant): This is a request for funds to purchase a Skyscan 1066 micro-CT for in vivo mouse imaging and ex vivo monkey tissue imaging at the Oregon National Primate Research Center (ONPRC) and Oregon Health & Science University (OHSU). The mission of the ONPRC is to move from basic science to pre-clinical monkey models to clinical research. As such this scanner which will allow both in vivo scanning of mice and ex vivo scanning of monkey tissues is uniquely suited to the mission of the ONPRC. We evaluated micro-CT scanners from Skyscan, Scanco, GE and Siemens. We chose the Skyscan 1076 because it has the greatest versatility in terms of high resolution (9 microns) and large maximum sample diameter (68 mm) for ex vivo scanning of monkey tissues and flexible resolution, scanning size and physiologic control and gating capacity for in vivo scanning. The research supported by the scanner will support key research areas of the ONPRC including reproductive biology, metabolic regulation, developmental biology and oncology. The scanner will also support cardiovascular research, oncology and endocrinology research by the ONPRC's host institution, OHSU. There will be 5 major users and 6 minor users. The major users will focus on oncofertility, obesity, lung disease and placental insufficiency, all areas of major importance to human health. Use of the system will be directed by a PhD biophysicist who also directs the ONPRC MRI core. A highly experienced small animal radiology technician will oversee day to day use and be responsible for training new users. An advisory committee of users, local, and national micro-CT experts will assist with administration and ensure appropriate training and data analysis. Strong institutional support will provide needed renovations to house the scanner, cover service contract costs and cover personnel costs of the technician and physicist. The scanner will fill a major need as there is no micro-CT scanner in the city of Portland, with the closest scanner located at Oregon State University, two hours driving time from Portland. PUBLIC HEALTH RELEVANCE: This instrument will support research on preserving fertility in cancer patients, research on combating obesity, research on preventing the effects of smoking during pregnancy on fetal development and research on placental problems during pregnancy. These are all major public health problems whose treatment will be significantly helped by the micro-CT scanner requested in this application.