A JEM 1400 Electron Microscope for a Core Facility

描述（由申请人提供）：本申请寻求资金购买JEOL JEM 1400电子显微镜，作为威尔康奈尔医学院和特殊外科医院核心设施研究的唯一电子显微镜。位于特殊外科医院的分析显微镜实验室（AML）已同意与威尔康奈尔医学院（WCMC）的电子显微镜和组织学核心设施合作，共同承担两家机构的透射电子显微镜服务的运营和维护成本。这两个机构紧挨着彼此，共享几个核心设施。共享现代电子显微镜的使用将提高两个机构的研究能力，并将提供更多获得专家技术援助的机会。在这个应用程序的参与者有项目，解决与应用到转化医学的主题，包括：细胞内的受体运输；神经发育与可塑性；血管生成;细胞分化，肌肉骨骼代谢和修复。这家合资企业的成功取决于设备的质量。所要求的显微镜JEOL JEM 1400是一种最先进的120千伏电子显微镜，具有额外的优势，可以升级仪器，包括先进的功能模块，如断层扫描和冷冻，成本相对较低。这将使联合设施在未来几年继续满足WCMC和HSS研究人员的需求，而无需投资另一个大型全尺寸仪器。

DESCRIPTION (provided by applicant): This application seeks funds to purchase a JEOL JEM 1400 electron microscope to serve as the sole EM available for research in a Core Facility at Weill Cornell Medical College and the Hospital for Special Surgery. The Analytical Microscopy Laboratory (AML), located at the Hospital for Special Surgery, has agreed to join with Electron Microscopy & Histology Core Facility at Weill Cornell Medical College (WCMC) to share the costs of operating and maintaining the transmission electron microscopy services for both institutions. The two institutions are immediately adjacent to each other and share several core facilities. Sharing the use of a modern electron microscope will enhance the research capabilities at both institutions, and it will provide increased access to expert technical assistance. The participants in this application have projects that address topics with applications to translational medicine including: receptor trafficking within cells; neural development and plasticity; angiogenesis; cell differentiation, and musculoskeletal metabolism and repair. The success of this joint venture is dependent on the quality of the equipment. The requested microscope, the JEOL JEM 1400 is a state of the art 120 kV electron microscope with added advantage that it is possible to upgrade the instrument to include advanced feature modules such as tomography and cryo in the field for relatively modest costs. This will enable the joint facilities to continue to meet the needs of the research faculties at both WCMC and HSS in future years without needing to invest in another large full-scale instrument.