High-throughput Workstation For Cell-based Assays

描述（由申请人提供）：西奈山医学院的研究人员需要一个用于细胞检测的高通量工作站。该系统包括与酶标仪（具有荧光、发光和吸光度检测）集成的液体处理器，用于处理和测量多孔测定板。西奈山的用户将使用该仪器开发和执行基于细胞的siRNA文库高通量筛选。该仪器将被安置在高内容筛选共享资源设施（HCS-SRF）中并由其维护，该设施是西奈山的一个集中组织，旨在为西奈山的研究人员提供全基因组siRNA筛选方法。该设施的两名专门的生物医学研究人员将为微孔板阅读器系统的用户提供持续的支持和培训，并将负责其维护。 项目说明：所要求的仪器将支持病毒学、神经学、肿瘤学和发育生物学的研究。该系统生成的信息可以帮助识别 用于治疗各种主要人类健康问题的新疗法，包括癌症、疼痛、流感和精神障碍，包括精神病。

DESCRIPTION (provided by applicant): A high-throughput workstation for cell-based assays is requested for the use for researchers at the Mount Sinai School of Medicine. This system is comprised of a liquid handler integrated with a plate reader (with fluorescence, luminescence and absorbance detection) for processing and measuring multiwell assay plates. Users at Mount Sinai will use the instrument for the development and execution of cell-based high-throughput screens of siRNA libraries. This instrument will be housed in and maintained by the High-Content Screening Shared Resource Facility (HCS-SRF), a centralized organization at Mount Sinai that is directed at providing access to genome-wide siRNA screening methods to Mount Sinai researchers. The facility's staff of two dedicated biomedical researchers will provide ongoing support and training for users of the microwell plate-reader system and will be responsible for its maintenance. PROJECT NARRATIVE: The requested instrument will support research in virology, neurology, oncology and developmental biology. The information generated on this system could help to indentify novel therapies for the treatment of a variety of major human health problems, including cancer, pain, flu, and psychiatric disorders, including psychosis.