Hamamatsu FDSS7000 Functional HTS Drug Screening System

描述（由申请人提供）：堪萨斯大学（KU）的高通量筛选核心设施（HTSC）寻求获得Hamamatsu FDSS 7000功能药物发现筛选系统，这是一种新型基于成像的平板阅读器，具有荧光和发光能力，用于离子通道和G蛋白偶联受体（gpcr）研究。几种疾病状态与离子通道和gpcr功能障碍有关，基于图像的平板阅读器已成为该研究领域使用的行业标准。目前，堪萨斯大学劳伦斯校区和堪萨斯城医学中心的教职员工没有能力进行FDSS7000提供的尖端GPCR和离子通道研究，因为在堪萨斯州或邻近的密苏里州、俄克拉荷马州和内布拉斯加州都没有这样的仪器。由于其具有行业经验的杰出员工和开放的服务政策，KUHTSC在学术HTS中心中取得了全国的突出地位。来自美国心脏地带各机构的许多研究人员依靠KUHTSC提供关键的研究和筛查支持。FDSS 7000对那些研究并不一定需要HTS的教员将有很大的帮助。KUHTSL帮助研究人员进行分析开发和高通量筛选。核心设施为研究人员提供教育资源，提供高温超导技术和实验方面所需的培训。

DESCRIPTION (provided by applicant): The High Throughput Screening Core Facility (HTSC) at the University of Kansas (KU) seeks to acquire a Hamamatsu FDSS 7000 functional drug discovery screening system, a novel imaging based plate reader with fluorescent and luminescent capabilities for use in ion channel and G protein coupled receptor (GPCRs) research. Several disease states are related to dysfunction in ion channels and GPCRs, and image based plate readers have become the industry standard for use in this area of research. At present, faculty at the KU Lawrence campus and the Medical Center in Kansas City do not have the ability to conduct cutting edge, GPCR and ion channel research afforded by the FDSS7000, as no such instrumentation is available anywhere in the state of Kansas, or in the neighboring states of Missouri, Oklahoma and Nebraska. KUHTSC has achieved national prominence among academic HTS centers because of its eminent staff with industrial experience and open service policy. A number of researchers from institutions across the Heartland of America depend on the KUHTSC to provide critical research and screening support. The FDSS 7000 would be of great assistance to faculty whose research does not necessarily require HTS as well. KUHTSL aids researchers in assay development and high through put screening. The core facility serves as an educational resource for researchers, providing needed training in HTS technology and experimentation. Acquisition of the FDSS7000 system would bolster our ongoing efforts in developing novel methods of biological analysis for Kansas researchers in multiple departments and campuses across a substantial diversity of research groups. It would also propel existing projects into active drug discovery programs involving high throughput screening of compound libraries. This core workstation will enable Kansas researchers to become significantly more competitive for external funding. This acquisition would complement our goals of a sustained coordinated effort to enhance multidisciplinary basic research related to the biological sciences across academic Kansas campuses. This system will help facilitate the hiring of bright, new investigators with innovative research projects. The broad, long term objectives of this application include research plans by multiple KU and KUMC faculty to develop novel projects around the technology afforded by the FDSS 7000 system. Our vision for the HTS core facility provides an avenue for a thriving research enterprise at KU, and helps in attracting and cultivating top research talent at KU and other Kansas State institutions.