Cu-64 Solid Target Handling System

描述（由申请人提供）：本提案的目标是获得资金，以在RDS 111生物医学回旋加速器中添加64Cu靶标和处理系统，以实现放射性核素64Cu的常规生产，用于体内分子成像研究。回旋加速器和拟议的靶系统被安置在分子和基因组成像中心，这是加州大学戴维斯分校的临床前核心设施，为动物模型的体内成像研究提供基础设施和专业知识。64cu标记的生物分子，包括64Cu-PTSM（用于灌注和细胞标记），64cu标记的肽，64cu标记的抗体，64cu标记的纳米颗粒和64cu标记的脂质体，正在被美国国立卫生研究院资助的加州大学戴维斯分校的一大批教师用作开发新的诊断和治疗药物的基础。64Cu的商业来源每14天只交付一次，大部分活动在运输中丢失。因此，美国国立卫生研究院资助的研究受到64Cu可用性的限制。我们建议增加一个64Cu靶和靶处理系统，使我们现有的RDS 111回旋加速器能够常规生产64Cu，为12名nih资助的研究人员在他们的研究项目中使用64Cu提供定期的64Cu。

DESCRIPTION (provided by applicant): The goal of this proposal is to secure funding to add a 64Cu targetry and handling system to a RDS 111 biomedical cyclotron to enable routine production of the radionuclide 64Cu for in vivo molecular imaging studies. The cyclotron and the proposed targetry system are housed in the Center for Molecular and Genomic Imaging, a preclinical core facility at UC Davis that provides the infrastructure and expertise to conduct in vivo imaging studies in animal models. 64Cu-labeled biomolecules, including 64Cu-PTSM (for perfusion and cell labeling), 64Cu-labeled peptides, 64Cu-labeled antibodies, 64Cu-labeled nanoparticles and 64Cu-labeled liposomes, are being used by a large group of NIH-funded faculty at UC Davis as the basis for the development of new diagnostic and therapeutic agents. Commercial sources for 64Cu only deliver once every 14 days, and large fractions of the activity are lost in transportation. Thus, NIH-funded research is limited by 64Cu availability. We propose the addition of a 64Cu target and target handling system that will enable routine production of 64Cu on our existing RDS 111 cyclotron, providing 64Cu on a regular basis for twelve NIH-funded researchers who utilize 64Cu in their research programs. PUBLIC HEALTH RELEVANCE: The field of molecular imaging seeks to discover new approaches to imaging specific biologic targets and pathways in vivo, with the ultimate goal of providing patient-specific and molecularly-based diagnostic information. In addition, molecular imaging approaches are being developed to directly monitor molecularly targeted therapies, cellular therapies and gene therapies. Positron emission tomography using radiolabeled tracers is a key platform technology for molecular imaging. The radionuclide copper-64 has a half-life compatible with the kinetics of many interesting biomolecules and is therefore an isotope with broad applications in the field. This proposal will enable routine production of copper-64 at UC Davis for application to research projects funded by NIH that involve the development of new diagnostic and therapeutic agents, and for tracking and visualization of stem and progenitor cell therapies.