MicroCT 100

描述（由申请人提供）：这是一份支持购买Scanco CT100标本微型计算机断层扫描仪（<CT）的提案，该扫描仪将成为密歇根大学牙科学院成像核心设施的一部分。该仪器将主要支持美国国立卫生研究院资助的牙科学院、工程学院、医学院和文学、科学和艺术学院的研究。所要求的仪器将通过使用自动样品转换器提供更高的吞吐量，更短的扫描和重建时间，提高分辨率和分析植入物等致密材料的能力，满足大学<CT未满足的需求。软件也将包括计算详细的骨组织形态学参数和进行有限元分析。仪器通量的增加将减少样品分析的周转时间，而分辨率的提高将允许分析微米范围内的结构，如小血管、骨微裂纹和牙本质小管。在骨生物学、组织工程和再生医学领域，密歇根大学是nih资助的研究人员最集中的大学之一，所有这些研究人员都将从购买该仪器中受益匪浅。目前，校园里只有一个CT标本，可以支持大约90名调查员。CT100将通过提供第二个高容量仪器来加速研究产出，并允许目前在该校园无法进行的新型分析。该提案包括维护和监督<CT设施的详细计划、包含适当用户收费表的财务计划和重要的长期机构支持。

DESCRIPTION (provided by applicant): This is a proposal to support the purchase of a Scanco CT100 specimen micro computed tomography scanner (<CT) that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry. This instrument will mainly support NIH-sponsored research in School of Dentistry as well in the College of Engineering, Medical School and College of Literature, Sciences and the Arts. The requested instrument will fulfill an unmet need for <CT at the University by providing increased throughput using an automatic sample changer, shorter scanning and reconstruction times, increased resolution and ability to analyze denser materials such as implants. Software will also be included to calculate detailed bone histomorphometric parameters and to conduct finite element analysis. Increased throughput of the instrument will reduce turnover times for sample analysis while increased resolution will allow analysis of structures in the micron range such as small blood vessels, bone microcracks and dentinal tubules. The University of Michigan has one of the highest concentrations of NIH-funded investigators in the areas of bone biology, tissue engineering and regenerative medicine, all of whom will greatly benefit from purchase of this instrument. Current, there is only a single specimen <CT on campus to support approximately 90 investigators. The CT100 will accelerate research output by providing a second high capacity instrument as well as allow new types of analysis that cannot presently be conducted on this campus. This proposal includes detailed plans for maintenance and oversight of the <CT facility, a financial plan with appropriate user fee schedules and significant long-term institutional support. PUBLIC HEALTH RELEVANCE: Three-dimensional micro-computed tomography (¿CT) has become a critically important standard technology in musculoskeletal and tissue engineering research. Use of this technology has greatly accelerated advances in the understanding of bone disease and the development of strategies for engineering functional tissues by providing quantitative measures of bone responses to physiologic, biologic, mechanical, pharmacologic or disease related influences. Since its introduction into biomedical research, this radiographic based tomographic technology, along with the development of computer reconstruction algorithms, has provided the capability to characterize bone structure as it had never been characterized before. As a result, ¿CT has had a significant impact on musculoskeletal health. This is a proposal to support the purchase of a Scanco CT100 specimen ¿CT system that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry and shared with other users in the Schools of Medicine, Engineering and Literature, Arts and Sciences. The requested instrument will fulfill an unmet need for ¿CT at the University by providing increased throughput, increased resolution and ability to analyze denser materials, enabling NIH-funded users to make further advances in health related research.