Smart Bio-Imaging

自从Robert Hooke首次应用显微镜（显微术，出版于1665年）以来，生物和医学科学完全依赖于这项技术及其随后的发现和健康/财富应用的所有发展。观察活细胞及其过程的愿望是当前显微镜进一步技术改进的持续驱动力，因为科学家们寻求观察和理解活生物体中的分子过程及其动力学。这个项目有两个主要目标，都是为了提高显微镜的性能。制造一种“智能相机”，可以追踪大量快速移动的粒子的位置。生产一种“智能相机”，可以跟踪对比度非常低的物体的位置，从而减少对可能严重损害细胞的荧光标记的需要。这项工作将以天文学自适应光学技术为基础。在这里，关键是要实时处理有关大气的数据，并将其反馈到可变形的镜子中，以纠正由光通过大气引起的扭曲。的气氛。

Since the first application of the microscopy by Robert Hooke (Micrographia, published in 1665), the biological and medical sciences have been entirely dependent upon this technology and all its subsequent developments for discovery and health/wealth applications. The desire to observe living cells and their processes is a continual driver for further technological enhancements of current microscopes as scientists seek to observe and understand the molecular processes and their dynamics in living organisms. This project has two major goals - both of which seek to enhance the performanc of microscopes 1. To produce a 'smart camera' which can track the position of a multitude of rapidly moving particles 2. To produce a 'smart camera' which can track the position of very low contrast objects which will reduce the need for fluorescent labelling of cells which can severely damage them. The work will be based on technology which has been developed for astronomical adaptive optics. Here it is critical to to process data about the atmosphere in real time and feed it back to a deformable mirror in order to correct for distortions caused by the passage of light through the atmosphere. atmosphere.