Formative Center for the Evaluation of Environmental Impacts on Fetal Development

描述（由申请人提供）：行政核心的主要目标是促进，组织和促进形成中心的跨学科研究和核心活动。项目主任/主要研究者将以最佳利用团队人才和技能的方式提供领导、监督和组织控制，以实现四个项目目标：1）在基础和临床研究中提供领导和创新，进一步了解环境压力及其对胎儿发育的影响，2）扩大跨学科研究，拓宽我们对与发育暴露相关的健康风险以及与疾病相关的潜在分子机制的理解，3）在各个领域之间建立桥梁，创造新的跨学科研究，培训和指导机会，以及4）有效地传达潜在的健康危害，并将基础研究成果转化为公共卫生。行政核心将通过发展组织结构和建立形成中心成员之间的沟通机制，与临床医生，研究人员，公众，NIEHS工作人员以及其他儿童环境健康中心和形成中心，作为该计划的中心。负责的财政和资源管理将是主要研究者的主要责任，由项目经理协助。行政核心将追求这些具体目标： 具体目标1：提供，支持和发展的过程，维持和适应跨学科的基础和应用研究和培训的增长。 具体目标2：维持一个加强团队建设和促进信息传播的沟通结构。 具体目标3：实施机制，将最佳地促进该计划的目标，并确保最好的和最负责任的使用可用资源。 公共卫生相关性：该形成中心的首要目标是开发新的生物标志物，用于影响胎儿发育并产生儿童和成人疾病的环境暴露的不良影响。使用跨学科的方法，研究，教育和培训干预措施将旨在解决孕妇，家庭和社区对环境化学品及其发育中儿童的健康的关注。

Description (provided by applicant): The primary objective of the Administrative Core is to promote, organize and facilitate the interdisciplinary research and core activities of the Formative Center. The Program Director/Principal Investigator will provide leadership, supervision and organizational control in a manner that best utilizes the team's talents and skills towards four programmatic objectives: 1) provide leadership and innovation in basic and clinical research that furthers our understanding of environmental stressors and their impact on fetal development, 2) expand interdisciplinary research that broadens our understanding of the health risks associated with developmental exposures and the underlying molecular mechanisms associated with disease, 3) build bridges across fields and create new interdisciplinary research, training, and mentoring opportunities, and 4) effectively communicate the potential health hazards and translate the basic research findings for the benefit of public health. The Administrative Core will function as the hub of the program by developing the organizational structure and creating mechanisms for communication among the members of the Formative Center, with clinicians, with researchers, with the public, with NIEHS staff, and with other Children's Environmental Health Centers and Formative Centers. Responsible fiscal and resource management will be the primary responsibility of the Principal Investigator, aided by the Program Manager. The Administrative Core will pursue these Specific Aims: Specific Aim 1: Provide, support and develop processes that sustain and accommodate the growth of interdisciplinary basic and applied research and training. Specific Aim 2: Maintain a communication structure that strengthens team building and facilitates the dissemination of information. Specific Aim 3: Implement mechanisms that will optimally promote the program's objectives and ensure the best and most responsible use of the available resources. Public Health Relevance: The over-arching goal of this Formative Center is to develop novel biomarkers for the adverse effects of environmental exposures that impact fetal development and produce childhood and adult disease. Using an interdisciplinary approach, research, educational, and training interventions will be designed to address the concerns that pregnant women, families, and communities have about environmental chemicals and the health of their developing children.