Training Grant in Lung Cell and Molecular Biology

描述(由申请人提供)： 该计划的主旨是为医学博士和博士后水平的医学博士和博士研究生提供至少两年半的肺部生物学研究培训，因为他们正在准备从事生物医学科学的学术研究事业。大部分研究实习生将来自每年为哈佛肺病和重症监护计划挑选的9名临床研究员。每个潜在的实习生，在项目负责人的指导下，将花费长达4个月的时间访问调查人员和实验室，以选择一个明确的调查主题。然后，受训者将与一名高级研究导师合作开发一个研究项目，其中包括一个可测试的机械假说，该项目将提交给培训补助金主任审查和批准。一旦项目获得批准，学员将在培训期间与该导师合作。19名优秀的教师(包括医学博士和博士)来自基础科学和临床系。培训的主要重点是在马萨诸塞州综合医院医学部的肺部和重症监护病房，但可以在哈佛系统的任何地方进行，例如在与麻省理工学院共享的布罗德研究所。四个专门的研究小组，肺损伤的细胞和分子生物学，职业医学和分子生物学，肺部炎症和正电子发射断层扫描，根据他们选择的研究项目，为每个受训者提供一个更加封闭和专注的环境。资深导师将密切监督学员的进度，并由项目主管定期进行审查。一个外部科学咨询委员会将每年审查整个计划，包括让受训者脱离他们的导师的行动。所有受训人员都必须参加负责任的科学调查行为课程。作为培训的一部分，将开设呼吸道生物学、流行病学和生物统计学、伦理学和临床有效性方面的具体课程。一支互动的、多学科的、国际公认的教师队伍为研究提供了一个强有力的、令人兴奋的智力环境。在培训期结束时，每个受训者都将在上述领域中的一个领域，如肺癌或哮喘，变得熟练并拥有适当的专业知识，以便能够在生物医学研究的学术环境中竞争进一步的培训或研究支持。

DESCRIPTION (provided by applicant): The main thrust of this program is to provide research training for a minimum of 2 1/2 years in pulmonary biology for M.D. and Ph.D. candidates at the postdoctoral level as they prepare to pursue academic research careers in biomedical sciences. The research trainees for the most part will come from the 9 clinical fellows selected each year for the Harvard Pulmonary and Critical Care Program. Each potential trainee, with guidance from the program directors, will spend up to 4 months visiting investigators and laboratories to choose a well-defined topic of investigation. The trainee will then work with a senior research mentor to develop a research project including a testable mechanistic hypothesis, which will be presented to the training grant directors for review and approval. Once the project is approved the trainee will work with that mentor for the duration of training. An outstanding faculty of 19 (both MD's and PhD's) is drawn from basic science and clinical departments. The primary focus of the training is in the Pulmonary and Critical Care Unit of the Department of Medicine at Massachusetts General Hospital, but can occur anywhere in the Harvard system such as at the Broad Institute shared with MIT. Four specialized research groups, cellular and molecular biology of lung injury, occupational medicine and molecular biology, lung inflammation, and positron emission tomography, provide each trainee a more cloistered and focused environment depending on their selected research project. The senior mentor will closely monitor the trainee's progress, with periodic review by program directors. An outside scientific advisory committee will review the entire program annually including movement of the trainee to become independent of their mentor. A course in Responsible Conduct of Scientific Investigation is required of all trainees. Specific courses in Biology of the Respiratory Tract, Epidemiology and Biostatistics, Ethics and Clinical Effectiveness will be offered as part of the training. An interactive, multi-disciplinary internationally recognized faculty provides a strong and exciting intellectual environment for research. At the conclusion of the training period, each trainee will have become adept and have appropriate expertise in one of the fields identified above, such as lung cancer or asthma, to be able to compete for further training or research support in an academic environment in biomedical research.