Diabetes Endocrinology Research Center

总体描述(由申请人提供)： 华盛顿大学糖尿病内分泌研究中心(DERC)是全国16个糖尿病中心之一。华盛顿大学DERC的目标是：1)向附属研究人员提供生物医学核心支持，2)创造一个环境，作为跨学科协作糖尿病研究的工具，3)赞助一个丰富计划，向糖尿病社区通报新的发展，并鼓励研究人员的互动和合作，4)进行试点和可行性小额赠款计划，以支持新研究人员的糖尿病研究，并为其他学科的现有研究人员提供机制，以启动糖尿病项目，5)开发新的研究方法和技术，并将其提供给糖尿病研究人员，以及6)作为大西雅图地区糖尿病研究活动的焦点和保护伞。为了实现这些目标，DERC围绕七个核心单元组成：行政核心、细胞生物学核心、临床研究核心、细胞和分子成像核心、分子遗传学核心、质谱学核心以及胰岛细胞和功能分析核心。通过提供的具体服务，包括新的开发工作，这些核心支持大约95名附属调查人员的研究。这项研究涵盖了糖尿病研究的全部领域，包括：a)1型糖尿病的病因和发病机制；b)2型糖尿病的病理生理学；c)肥胖与体重和成分的调节；d)临床试验和大规模流行病学研究；e)脂蛋白生理学和动脉粥样硬化；以及f)糖尿病和老龄化的并发症。为了改善华盛顿大学糖尿病研究的科学环境，并促进合作，DERC的丰富计划提供了研讨会系列、年度核心研讨会和访问科学家计划。作为该中心致力于促进对糖尿病研究感兴趣的初级教员的职业发展的一部分，DERC每年提供20万美元，支持糖尿病研究新手的试点和可行性补助金。

DESCRIPTION, OVERALL (provided by applicant): The Diabetes Endocrinology Research Center (DERC) at the University of Washington is one of a total 16 Diabetes Centers nationwide. The objectives of the University of Washington DERC are to: 1) provide biomedical core support to Affiliate Investigators, 2) create an environment and serve as a vehicle for interdisciplinary collaborative diabetes research, 3) sponsor an enrichment program to inform the diabetes community of new developments, and to stimulate interaction and collaboration of investigators, 4) conduct a pilot and feasibility small grant program to support diabetes research by new investigators and to provide a mechanism for established investigators in other disciplines to initiate projects in diabetes, 5) develop new research methodologies and technologies and make these available to diabetes investigators, and 6) to serve as both a focal point and an umbrella for diabetes research activities in the greater Seattle area. To accomplish these goals, the DERC is organized around seven Core units: the Administrative Core, Cellular Biology Core, Clinical Research Core, Cellular and Molecular Imaging Core, Molecular Genetics Core, Mass Spectrometry Core, and the Islet Cell and Functional Analysis Core. Through specific services provided, including new developmental work, these Cores support the research of approximately 95 Affiliate Investigators. This research covers the entire spectrum of diabetes investigation including, a) etiology and pathogenesis of type 1 diabetes, b) pathophysiology of type 2 diabetes, c) obesity and regulation of bodyweight and composition, d) clinical trials and large-scale epidemiologic studies, e) lipoprotein physiology and atherosclerosis, and f) complications of diabetes and aging. To enhance the scientific environment for diabetes research at the University of Washington and to stimulate collaboration, the DERC's Enrichment Program provides a Seminar Series, an annual Core Symposium, and a Visiting Scientist Program. As part of the Center's commitment to fostering the career development of junior faculty interested in diabetes research, each year the DERC provides $200,000 to support pilot and feasibility grants of investigators new to diabetes research.