Genetic Analysis: Psychiatric and Other Complex Diseases

描述（由申请人提供）：这是一个建议，继续在精神病和其他复杂疾病的遗传流行病学和统计分析成功的研究培训计划。精神病遗传学领域正在迅速变化，成功的研究人员必须能够胜任广泛的技术，必须能够说自己领域之外的语言，并且必须能够与其他领域的科学家有效合作。该计划培养博士后（医学博士，哲学博士、（Dr.P.H.）和博士前研究员培训包括（a）教学和（B）研究两部分。(a)教学部分被进一步分解为一个学术课程和一系列实际的实验室轮换。学术课程包括人类遗传学，流行病学，统计遗传学，计算机模拟，研究沟通技巧和负责任的研究行为等一系列学术课程。实验室轮换发生在哥伦比亚大学的一些实验室，在那里正在进行丰富而广泛的遗传研究。(b)在研究部分，每个研究员与导师密切合作，进行研究员选择的独立研究项目;研究员准备一份明确的书面研究提案，执行提案，准备口头说明研究及其结果，并根据完成的研究准备一份可编辑的手稿。培训结束时，研究员了解：遗传对疾病风险影响的生物学基础;如何在人类遗传学中提出可检验的假设并设计研究来检验这些假设;表型定义的至关重要性;如何设计遗传研究的数据收集战略;选择适当样本的因素;负责任地开展研究和良好临床实践的问题;遗传分析的数学基础，包括家族聚集性研究、双胞胎研究、分离、连锁和关联分析;实验室技术，如基因分型和测序、从血液中提取DNA、PCR等;通过使用数据库管理系统对遗传和临床数据进行适当的数据管理;如何使用当前的遗传分析程序，解释结果，并在新的遗传分析方法可用时对其进行测试和评估;以及微阵列技术和其他当前的分子生物学技术。

DESCRIPTION (provided by applicant): This is a proposal to continue a successful research training program in the genetic epidemiology and statistical analysis of psychiatric and other complex diseases. The field of psychiatric genetics is changing rapidly, and successful investigators must be competent in a broad array of techniques, must be able to speak the languages of fields outside their own, and must be able to collaborate effectively with scientists in other fields. The program trains postdoctoral (M.D., Ph.D., and Dr.P.H.) and predoctoral Fellows. Training has both (a) didactic and (b) research components. (a) The didactic component is further broken down into an academic program and a series of practical laboratory rotations. The academic program includes a series of academic courses in human genetics, epidemiology, statistical genetics, computer simulations, research communication skills, and responsible conduct of research. The laboratory rotations take place in a number of laboratories at Columbia University, where a rich and broad variety of genetic studies are being carried out. (b) In the research component each Fellow works closely with a Preceptor on an independent research project of the Fellow's choosing; the Fellow prepares a clearly written research proposal, carries out the proposal, prepares an oral description of the study and its results, and prepares a publishable manuscript based on the completed study. At the end of training, Fellows understand: the biological underpinnings of genetic influences on disease risk; how to formulate testable hypotheses in human genetics and design studies to test those hypotheses; the critical importance of phenotype definition; how to design data collection strategies for genetic studies; the factors that go into selecting appropriate samples; issues of responsible conduct of research and Good Clinical Practice; the mathematical underpinnings of genetic analysis, including familial aggregation studies, twin studies, and segregation, linkage, and association analysis; laboratory techniques such as genotyping and sequencing, extracting DMA from blood, PCR, etc.; proper data management of genetic and clinical data through the use of a data base management system; how to use current genetic analysis programs, to interpret the results, and to test and evaluate new methods of genetic analysis as they become available; and microarray technology and other current molecular-biological techniques.