CORE E: BIOREPOSITORY CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 具体目标 1)为Cobre研究人员提供为人类主题研究服务的集中注册和存储库资源支持。 2)为Cobre研究人员提供其研究所需的样本和数据。 OMRF的Cobre研究人员可以获得多种人类研究资源。这些资源包括俄克拉荷马州风湿病资源核心中心(ORDRCC)、狼疮家庭登记和存储库(LFRR)、俄克拉荷马州狼疮队列(OLC)、俄克拉荷马州自动化联合卓越中心(OK-ACE)资源、俄克拉荷马州干燥综合征队列和科布雷社区参与样本。NIAMS、NIAID和NCRR资助的每个项目都收集了各种样本，包括血清、血浆、外周血细胞、组织以及详细的临床、人口统计学、实验测试和环境数据。LFRR成立于1995年，已经招募了2600多名狼疮患者和7500多名对照和家庭成员，这些人已经被用于一系列持续的高度信息量的遗传学研究。Cobre初级调查人员本身不是ACE的一部分，也可能不是LFRR(这一审批过程需要18个多月才能完成)的批准用户。因此，这一核心提供了一个集中的访问点，以帮助初级Cobre调查人员确定可能的资源、选择要使用的样本、获取样本并收集关于相同个人的可用协作数据。如有必要，可通过该中心为Cobre初级调查员安排额外的新样本招聘。Cobre初级研究人员利用这一核心的例子包括获取基因组DNA、冷冻的PBMC和EBV转化细胞，以及将Sjogren的患者引入Maier-Moore博士。同样，该核心为Wiley博士的Exome测序项目提供了数百名受试者的大量基因组DNA，并在我们的存储库中为Montgomery博士发现了额外的血清样本，用于抗病毒抗体测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Specific Aims 1) To provide support for centralized registry and repository resource servicing human subject research for COBRE researchers. 2) To provide COBRE investigators access to samples and data for their studies. Multiple resources for human research are available to COBRE investigators at the OMRF. These include the Oklahoma Rheumatic Disease Resources Cores Center (ORDRCC), Lupus Family Registry and Repository (LFRR), Oklahoma Lupus Cohort (OLC), Oklahoma Automunity Centers of Excellence (OK-ACE) resources, Oklahoma Sjogren's Syndrome Cohort, and COBRE Community Engagement samples. Each of these NIAMS, NIAID and NCRR funded projects has collected an assortment of samples including serum, plasma, peripheral blood cells, tissue as well as detailed clinical, demographic, experimental test and environmental data. The LFRR, which was established in 1995, has recruited over 2600 lupus patients and over 7500 controls and family members that have been used in a continuing series of highly informative genetic studies. COBRE junior investigators are themselves not part of the ACE and are likely not approved users of the LFRR (an approval process which requires over 18 months to accomplish). As such, this Core provides a centralized access point to help junior COBRE investigators identify possible resources, select samples to use, procure samples and gather available collaborative data about the same individuals. As necessary, additional recruiting of fresh samples for COBRE junior investigators can be arranged through this Core. Examples where this Core has been utilized by junior COBRE investigators include access to genomic DNA, frozen PBMC and EBV transformed cells and bringing in Sjogren's patients for Dr. Maier-Moore. Similarly, this Core has provided Dr. Wiley with large amounts of genomic DNA from hundreds of subjects for his Exome sequencing projects and has found additional serum samples in our repository for Dr. Montgomery for anti-viral antibody testing.