CORE B: NUCLEIC ACID ANALYSIS CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 核酸分析核心的目标是为COBRE研究人员提供在核酸水平上研究分子机制的资源和专业知识。 为了实现这些目标，COBRE研究人员可以获得专门的设备，培训和开发以及实验设计。 核酸分析核心的功能为初级研究人员提供了一个单一的切入点，为核酸实验操作的技术方面提供全面的建议（指导），获得训练有素的技术人员以及非常复杂和昂贵的设备。核心将提供检测开发、数据收集或核苷酸合成。该核心集中了高效可靠地生成高质量核酸分析数据所需的设备和经验。通过该核心提供的服务包括DNA测序、单核苷酸多态性（SNP）基因分型、小鼠和人的表达阵列以及SNP阵列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of the Nucleic Acid Analysis Core is to provide COBRE investigators with resources and expertise to study molecular mechanisms at the nucleic acid level. To meet these goals, COBRE investigators are given access to specialized equipment, training and development, and design of experiments. The capabilities, assembled in the Nucleic Acid Analysis Core, provide the Junior Investigators a single point of entry, comprehensive advice (mentoring) for the technical aspects of experiments manipulating of nucleic acids, access to highly-trained technical personnel, and very sophisticated and expensive equipment. The Core will offer assay development, data collection, or nucleotide synthesis. This Core centralizes the equipment and experience needed to efficiently and reliably produce high quality nucleic acid analysis data. The services available through this Core include DNA sequencing, single nucleotide polymorphism (SNP) genotyping, expression arrays in mouse and man, and SNP arrays.