OK COBRE: NUCLEIC ACID ANALYSIS CORE

描述(由申请人提供)：俄克拉荷马医学研究基金会(OMRF)在此建议设立一个生物医学研究卓越中心(COBRE)，主题是“自身免疫的分子机制和遗传学”。免疫学和风湿病的研究项目是在20多年前由OMRF发起的，自那以来一直稳步增长。该教员负责许多开创性的发现，并使这一领域成为OMRF的优秀研究领域，以此为基础建立科布雷。我们推荐四名初级研究人员，他们在自身免疫的遗传学和分子机制方面有很好的生物医学研究生产力。事实上，他们的项目应该对我们理解重要的自身免疫性疾病问题产生重要影响。这些初级调查人员得到了八位杰出导师的支持，他们将提供指导和宣传，这对独立科学家的成功职业生涯非常重要。初级调查人员提议的项目还将得到核酸分析核心和数据分析核心的协助，这两个核心都是由非常有经验和知识渊博的科学家指导的。事实上，这些核心将有助于有效和经济地将最先进的技术和方法应用于初级调查员执行的项目中正在解决的问题。该中心将招募更多的Cobre初级研究人员，使其成为发展许多独立调查人员的过渡机制，从而保持俄克拉荷马州目前在自身免疫研究方面取得的卓越水平。科布雷的协同作用、合作和定向努力将提供对人类自身免疫性疾病的更深层次的了解，并将促进一支强大的初级研究人员团队的独立职业发展。

DESCRIPTION (provided by applicant):The Oklahoma Medical Research Foundation (OMRF) herein proposes a site for a Center for Biomedical Research Excellence (COBRE) on "Molecular Mechanisms and Genetics of Autoimmunity." Research programs in immunology and rheumatic diseases were initiated over 20 years ago at the OMRF and have been steadily growing since. The faculty is responsible for a number of seminal discoveries and has made this an area of research excellence at the OMRF upon which to build this COBRE. We propose four Junior Investigators who have promising futures for biomedical research productivity in the genetics and molecular mechanisms of autoimmunity. Indeed, their projects should have an important impact upon our understanding of important autoimmune disease problems. These Junior Investigators are supported by eight exceptional Mentors, who will provide the guidance and advocacy so important for launching the successful careers of independent scientists. The projects proposed by the Junior Investigators will also be facilitated by a Nucleic Acid Analysis Core and a Data Analysis Core, both of which are directed by very experienced and knowledgeable staff scientists. Indeed, these cores will help efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed in the projects performed by the Junior Investigators. Additional COBRE Junior Investigators will be recruited to this center making this a transitional mechanism for the development of many independent investigators, thereby sustaining the level of excellence now achieved in research into autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.