Molecular Regulation of Cell Development and Differentiation

申请五年资金，在堪萨斯大学医学中心（KUMC）建立一个卓越生物医学研究中心，重点研究细胞发育和分化的分子调控。我们选择了五名有共同研究兴趣的新教师，目的是帮助他们成为受资助的独立研究者。为了实现这一目标，已经组建了一个PI、两个共同PI、一个内部咨询委员会（IAC）、一个指导教师小组和一个由杰出调查人员组成的外部咨询委员会（EAC）。该中心还旨在改善KUMC的基础设施和研究环境。该计划的预期结果将是更高的研究生产力，这反映在联合出版物、资助的R01拨款以及基于发育生物学主题的计划项目和研究中心拨款中。每个初级教员都被分配了一名导师，并制定了个人指导计划和时间表。指导计划的主要特点包括由导师和咨询委员会对研究项目进行持续的批判性评价，与咨询委员会成员举行半年一次的会议，以及在讲习班上进行关于统计、手稿和拨款写作的特别培训。最初的小组将获得长达3年的支持。在此时间框架内，每位成员将有望成功竞争NIH r01型研究支持。一旦获得外部资助，他们将在财政上轮换拨款，为增加新的初级教员腾出空间，我们已经得到了提供这些新教员的系主任/中心主任的坚定承诺。该基金将在5年内资助10-15名独立研究人员。另一个重要的特点是建立3个新的科学核心能力，为中心的教师提供额外的研究支持。与行政核心A一起，将有支持转基因、基因靶向和基因分型（核心B）、分子分析和重组（分子核心C）和高分辨率成像（核心D）的核心。总之，卓越的科学人才、现有的研究环境、新的核心设施和大量的机构承诺的杰出结合，确保了这个拟议的中心将促进一个主题的多学科研究工作的发展，提高新研究者独立竞争NIH和其他外部支持的能力，并加强KUMC的整体研究基础设施。

Five years of funding are requested to develop a Center of Biomedical Research Excellence at the University of Kansas Medical Center (KUMC) with a focus on the molecular regulation of cell development and differentiation. Five talented new faculty who share this research interest were selected with the goal of helping them become funded independent investigators. A PI, two co-PIs, an internal advisory committee (IAC), a group of mentoring faculty, and an external advisory committee (EAC) of distinguished investigators have been assembled to achieve this goal. The Center is also designed to improve the infrastructure and research environment at KUMC. The expected outcome of the program will be more research productivity as reflected in joint publications, funded R01 grants, and program project and research center grants based on a developmental biology theme. A mentor has been assigned to each initial junior faculty member, and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research projects by mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing in workshops. The initial group will receive support for up to 3 years. Within this time frame, each member will be expected to compete successfully for NIH R01-type research support. Once funded externally, they will rotate off the grant financially to make room for the addition of new junior faculty, and we have firm commitments from Department Chairs/Center Directors who will provide these new faculty. Over 5 years, the grant will support 10-15 independent researchers. Another important feature is to establish 3 new scientific Core capabilities to provide additional research support for the Center's faculty. Together with the Administrative Core A, there will be Cores supporting transgenesis, gene targeting and genotyping (Core B), molecular profiling and recombineering (Molecular Core C) and high resolution imaging (Core D). In summary, the outstanding combination of exceptional scientific talent, existing research environment, requested new Core facilities, and substantial institutional commitment, ensure that this proposed Center will foster the development of a thematic, multidisciplinary research effort, enhance the ability of new investigators to compete independently for NIH and other extramural support, and strengthen the overall research infrastructure at KUMC.