NEUROPATHOLOGY CORE

太平洋西北痴呆和老龄化(PANDA)神经病理学(NP)小组是俄勒冈健康与科学大学(OHSU)的阿尔茨海默病(AD)中心(ADC)和华盛顿大学(UW)的AD研究中心(ADRC)于2003年7月发起的合作成果。熊猫NP Group最初的四个具体目标与我们之前的申请没有变化： 1.根据最新的标准化诊断标准，及时向死者家属和参与护理的医生提供尸检报告，从而向太平洋西北地区的不同人口提供诊断专业知识。 2.通过收集、存储和分发高度可访问、但受到适当保护的脑组织和神经病理数据储存库来促进研究，这些数据来自仔细和纵向表征的轻度认知障碍(MCI)或痴呆症患者以及非认知障碍对照个人，使用各种方法最大限度地提高科学家的效用。 3.向病理学、神经学、心理学、精神病学和基础科学的学员讲授神经退行性疾病和年龄相关变化的神经病理学分类的现行方法，并指导NP的初级教员。 4.开发创新的新办法，最大限度地实现目标1至3的成就。 两个新的具体目标集中在靶向分子测试上： 5.量化UW ADRC CSF库中的目标脑脊液(CSF)生物标志物，这些生物标志物主要来自OHSU ADC和UW ADRC临床核心，以提高这些标本的研究价值，同时确保适当的保护措施。 6.提供与阿尔茨海默病和相关疾病相关的DNA和定向基因检测的专家准备 神经退行性疾病。

The Pacific Northwest Dementia and Aging (PANDA) Neuropathology (NP) Group is a cooperative effort between the Alzheimer's Disease (AD) Center (ADC) at Oregon Health & Science University (OHSU) and the AD Research Center (ADRC) at the University of Washington (UW) that was initiated in July 2003. The initial four Specific Aims of the PANDA NP Group are unchanged from our previous applications: 1. Provide diagnostic expertise to the diverse population of the Pacific Northwest by providing family members of the deceased and physicians involved in their care with timely autopsy reports based on the most current standardized diagnostic criteria. 2. Facilitate research by collecting, storing and distributing a highly accessible, but appropriately safeguarded, repository of well-prepared brain tissue and neuropathologic data from carefully and longitudinally characterized patients with mild cognitive impairment (MCI) or dementia as well as noncognitively impaired control individuals using a variety of methods that maximizes utility to scientists. 3. Teach trainees in pathology, neurology, psychology, psychiatry, and basic sciences the current methods of neuropathological classification of neurodegenerative diseases and age-related changes, and mentor junior faculty in NP. 4. Develop innovative new approaches to maximize achievements in Aims 1 to 3. Two new Specific Aims are focused on Targeted Molecular Testing: 5. Quantify targeted cerebrospinal fluid (CSF) biomarkers in the UW ADRC CSF Bank that derives in large part from the OHSU ADC and UW ADRC Clinical Cores to enhance the value of these specimens for research while insuring proper safeguards. 6. Provide expert preparation of DNA and targeted genetic testing relevant to AD and related neurodegenerative diseases.