Center for Metabolic Research on HIV and Drug Use

描述（由申请人提供）：五年前，Tufts营养合作-药物滥用和艾滋病研究中心（TNC-CDAAR）由NIDA资助，只是全国两个CDAAR之一。药物滥用和成瘾研究中心的任务如下：促进对药物滥用和成瘾研究的合作方法；使没有研究中心独特的气候、设施和资源就无法进行的研究成为可能；作为一种资源，吸引已有的和有前途的调查人员从事药物滥用研究；并提供研究培训、职业发展和指导的机会。TNC-CDAAR是由三家东海岸机构（塔夫茨大学、布朗大学和约翰霍普金斯大学）合作成立的，重点是研究营养和健康。艾滋病毒阳性和艾滋病毒阴性吸毒者之间的代谢紊乱。在过去的五年中，我们扩大了TNC-CDAAR的范围，吸纳了来自阿根廷、印度和越南这三个国家的合作者。到目前为止，我们的主要成就是：1)设计并实施了几项新的研究，以评估和比较美国和国外不同种族的吸毒者中特定营养和代谢紊乱的患病率和发病率；2)为希望在当地进行类似研究的研究者制定培训材料、规程和手册；3)协助中心相关研究领域的新拨款提案；4)成为吸毒者营养和代谢紊乱的资源中心。TNC-CDAAR将继续运作其原来六个核心中的五个：行政（核心A）、发展（核心B）；吸毒者资源（核心C）；营养与代谢（核心D）；流行病学和生物统计学（核心F）。核心E（内分泌）将与核心D合并，并将增加新的肝炎和肝功能核心（核心G）。这个新的核心是根据TNC-CDAAR调查人员和成员的需要而开发的，他们发现营养和代谢异常不仅可能与艾滋病毒有关，而且可能与吸毒者的慢性肝病有关。本中心将继续努力提高人们对药物使用人群中营养和代谢紊乱对结果的重要性的认识，并鼓励研究人员将营养和代谢状况的研究纳入其对药物使用人群的研究。五个中心核心将继续协同工作，为中心成员提供多种服务。

DESCRIPTION (provided by applicant): Five years ago, the Tufts Nutrition Collaborative - Center for Drug Abuse and AIDS Research (TNC-CDAAR) was funded by NIDA as just one of two CDAAR's in the nation. The CDAARs were charged with the following mission: to foster a collaborative approach to drug abuse and addiction research; to enable studies that would not occur without the climate, facilities, and resources that a research center can uniquely provide; to serve as a resource to attract established and promising investigators into drug abuse research; and to provide opportunities for research training, career development, and mentoring. The TNC-CDAAR was formed as a partnership between three East Coast Institutions (Tufts, Brown and Johns Hopkins) with a specific focus on studying nutritional and .metabolic disorders among HIV-positive and HIV-negative drug users. Over the past five years, we have expanded the TNC-CDAAR to include collaborators from 3 international sites: Argentina, India, and Vietnam. Our major accomplishments, thus far, have been to 1) design and implement several new studies to assess and compare the prevalence and incidence of specific nutritional and metabolic disorders in drug users of different ethnicities, both in the U.S. and abroad; 2) develop training materials, protocols, and manuals for investigators who want to undertake similar studies in their localities; 3) help in the development of new grant proposals in Center-related areas of research; and 4) become a resource center on nutrition and metabolic disorders in drug users. The TNC-CDAAR will continue to operate five of its original six cores: Administrative (Core A), Developmental (Core B); Drug User Resources (Core C); Nutrition and Metabolism (Core D); and Epidemiology and Biostatistics (Core F). Core E (Endocrine) will be merged with Core D and a new Core on Hepatitis and Liver Function (Core G) will be added. This new Core was developed in response to the needs of TNC-CDAAR Investigators and Members who have found that nutritional and metabolic abnormalities are likely linked not only to HIV, but also to chronic liver disease among persons who use drugs. The Center will continue to work to raise awareness of the importance of nutritional and metabolic disorders on outcomes in the drug using population and to encourage investigators to include studies of nutritional and metabolic status in their research in drug using populations. The five Center Cores will continue to work synergistically to provide a multitude of services for Center Members.