Arkansas Integrative Metabolic Research Center

阿肯色州综合代谢研究中心(AIMRC)总体部的项目摘要： 阿肯色大学费耶特维尔分校(U Of A)是阿肯色州的旗舰校区，但不是 在校园里有活跃的NIH Cobre基金。生物医学研究领域的明显优势已经有机地显现出来。 在校园里，国立卫生研究院在亚利桑那州大学的大部分资金都涉及细胞和组织新陈代谢的研究。这 NIH资助的校园研究人员将在以下地址发起和发展一个跨学科研究中心 阿肯色州大学命名为阿肯色州综合代谢研究中心(AIMRC)。凯尔·奎恩医生 新陈代谢成像和生物医学光学领域的知名领导者，与 NIH资助的其他在校代谢研究人员将指导该中心。AIMRC的科学主题 是通过研究了解细胞和组织新陈代谢在疾病、发育和修复中的作用 涉及先进的成像、生物能量学和数据科学。通过阐明两者之间的复杂关系 使用已建立的生物能量分析、先进的无标记成像技术 技术和尖端数据科学方法、新的治疗靶点和机械洞察力可以 被确定为建立各种疾病的新治疗方法。AIMRC将有一个 行政核心、三个研究核心和四个由初级调查员项目负责人领导的研究项目。 行政核心将协调中心活动，监督初级教师的招聘和指导， 并协调一个试点项目计划。AIMRC将投资于现有的最先进的显微镜服务 在校园建立一个专注于无标记代谢成像和光谱成像的成像和光谱核心 光谱学。生物能量学核心公司将联合使用最先进的活细胞代谢分析平台 利用成熟的流式细胞仪工具，提供对线粒体和代谢健康的定量了解 细胞的数量。通过利用我们的高性能计算，还将建立数据科学核心 校园中的资源和专业知识，帮助研究人员分析、集成和综合 由研究核心和中心成员生成的数据集。AIMRC将支持四名初级教职员工 成员领导研究项目，研究细胞和组织新陈代谢的不同方面，包括： 了解乳腺癌的神经支配机制，评价翻译后的效果 乳腺癌的修饰，评估蛋氨酸代谢对黑色素瘤的影响，并阐明细胞 上皮形态发生过程中的信号和线粒体动力学。近期的目标是跟随一个中锋 组织和管理计划，通过招聘、开发和管理建立中心的基础 指导初级调查员。最终，我们计划将该中心发展到足够多的研究人员 支持该中心，并使其在代谢研究的广泛外部支持方面具有竞争力。

Project Summary for Overall Section of the Arkansas Integrative Metabolic Research Center (AIMRC): The University of Arkansas - Fayetteville (U of A) is the flagship campus of the State of Arkansas, but does not have active NIH COBRE funding on campus. A clear strength in biomedical research has emerged organically on campus, with the majority of NIH funding at the U of A involving research on cell and tissue metabolism. This collection of NIH-funded researchers on campus will initiate and develop a cross-disciplinary research center at the University of Arkansas titled, the Arkansas Integrative Metabolic Research Center (AIMRC). Dr. Kyle Quinn, an established leader in the field of metabolic imaging and biomedical optics, with ongoing collaborations with the other NIH-funded metabolic researchers on campus will direct the center. The scientific theme of the AIMRC is to understand the role of cell and tissue metabolism in disease, development, and repair through research involving advanced imaging, bioenergetics, and data science. By elucidating the complex relationship between metabolism and different disease states using established bioenergetics assays, advanced label-free imaging technology and cutting-edge data science approaches, novel therapeutic targets and mechanistic insights can be identified to establish new treatment approaches for a variety of diseases. The AIMRC will have an administrative core, three research cores, and four research projects led by junior investigator Project Leaders. The Administrative Core will coordinate center activities, oversee the recruitment and mentoring of junior faculty, and coordinate a Pilot Project Program. The AIMRC will invest in existing state-of-the-art microscopy service centers on campus to establish an Imaging and Spectroscopy Core focused on label-free metabolic imaging and spectroscopy. A Bioenergetics Core will employ state-of-the-art live cell metabolic assay platforms in conjunction with established flow cytometry tools to provide quantitative insights into the mitochondrial and metabolic health of the cells. A Data Science Core will also be established by leveraging our high-performance computing resources and expertise on campus to assist researchers with analyzing, integrating, and synthesizing large datasets generated by the research cores and center members. The AIMRC will support four junior faculty members to lead Research Projects to study different aspects of cell and tissue metabolism that include: understanding the mechanisms of breast cancer innervation, evaluating the effects of post-translational modifications in breast cancer, evaluating the effect of methionine metabolism in melanoma, and elucidating cell signaling and mitochondrial dynamics during epithelial morphogenesis. The near-term goal is to follow a center organization and management plan to establish the foundation of the center by recruiting, developing, and mentoring junior investigators. Ultimately, we plan to grow the center to a critical mass of researchers that sustains the center and allows it to be competitive for a wide range of extramural support in metabolic research.