Non-Invasive Image-Guided HIFU for Breast Cancer Therapy

描述（由申请人提供）：MRI的改进现在使得开发和实施范式转换，在线模型预测控制系统成为可能，使热治疗更加准确和临床实用。我们的目标是在一种全新的、完全无创的、mri引导的、相控阵HIFU加热系统中开发和使用这样的控制器，该系统专为乳腺肿瘤的热治疗而设计。这是一个重要的临床场所，有大量的患者，目前的治疗方法可以显著改善。提出的系统有几个独特的创新，包括：一个新的，乳房专用的，HIFU相控阵加热系统与集成的MRI接收器线圈；一种最优、自适应、模型预测控制系统；先进的磁流变温度测量技术；基于创新的MR组织特性和灌注测量的患者特异性治疗计划；交互式3D显示器，用于临床医生的治疗监测和监督控制。这些创新将通过犹他大学（UU）、西门子医疗解决方案（SMS）和图像引导治疗（IGT）的跨学科科学家、工程师和临床医生之间密切的学术/工业合作伙伴关系来实现。这种新颖的集成系统及其创新的改进不仅将显著推进乳腺肿瘤热疗法的发展，而且将适用于所有临床场所。

DESCRIPTION (provided by applicant): Improvements in MRI have now made it possible to develop and implement paradigm-shifting, on-line model- predictive control systems to make thermal therapy treatments more accurate and clinically practical. Our goal is to develop and use such a controller in a novel, completely non-invasive, MRI-guided, phased array HIFU heating system, designed specifically for thermal therapy of breast tumors. This is an important clinical site with a large population of patients for whom current treatments can be significantly improved. The proposed system has several unique innovations including: a new, breast-specific, HIFU phased array heating system with integrated MRI receiver coils; an optimal, adaptive, model-predictive control system; advanced MR temperature measurement techniques; patient-specific treatment planning based on innovative MR tissue- property and perfusion measurements; and interactive 3D displays for clinician treatment monitoring and supervisory control. These innovations will be achieved through the close academic/industrial partnership between interdisciplinary scientists, engineers and clinicians at the University of Utah (UU), Siemens Medical Solutions (SMS) and Image Guided Therapy (IGT). This novel integrated system and its innovative improvements will not only significantly advance the state of the art of thermal therapies for breast tumors, but for all clinical sites. PUBLIC HEALTH RELEVANCE: This study will develop and test an improved, completely non-invasive system for breast cancer thermal therapy at high temperatures. The system will consist of a specially designed ultrasonic, phased array designed heating applicator that is coupled with an MRI imaging system. Together, they will heat the tumor and measure its temperature non-invasively, with both the heating system and the imaging system under guided by a novel, model predictive control system that will keep the patient safe while delivering an effective, practical treatment.