COBRE: UAF: BIOLOGICAL SPECIMENS AND GENETICS CORE C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物标本和遗传学(BSG)核心提供必要的关键服务，以促进遗传学家、统计学家、流行病学家、心理学家和社区领袖之间的合作调查，旨在了解爱斯基摩人肥胖相关风险因素的相互作用。此外，BSG核心还提供有价值的社区和全州范围内的服务，涉及阿拉斯加原住民农村社区进行尊重文化的基因研究的道德行为。BSG核心通过就遗传在疾病病因学中的作用以及使用最大限度保护参与和非参与社区成员隐私的方法确定家庭关系向新的研究人员提供建议，以实现这些目标。BSG Core确保生物样本经过处理以保持样本的完整性并存储在安全的设施中，并维护一个样本数据库以管理和跟踪运往合作实验室的样本。此外，BSG核心为新的研究人员和学生提供基因分型专业知识。最后，BSG核心将建立一个社区咨询委员会，每年举行一次会议，并与国家遗传学咨询委员会合作，建立收集和使用生物样本的伦理程序，以及利用基于社区的参与性研究框架传播遗传结果。 BSG核心的设计是基于我们在CANHR研究第一阶段中对Genetics核心的经验和使用，以及我们社区合作伙伴和部落长老声明的健康优先事项。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Biological Specimens and Genetics (BSG) Core provides key services necessary to facilitate collaborative investigations between geneticists, statisticians, epidemiologists, psychologists, and community leaders that are aimed at understanding the interaction of obesity-related risk factors in Yup'ik Eskimos. Additionally, the BSG core provides valuable community, and state-wide services related to the ethical conduct of culturally respectful genetic studies in rural Alaska Native communities. The BSG Core accomplishes these objectives by advising new investigators on the role of heredity in disease etiology, and on the ascertainment of familial relationships using methods that maximize the privacy of participating and non-participating community members. The BSG Core ensures that biological samples are processed to retain sample integrity and stored in a secure facility, and maintains a specimen database to manage and track samples shipped to collaborating laboratories. In addition, the BSG Core provides genotyping expertise to new investigators and students. Finally, the BSG Core will establish a Community Advisory Board that will meet annually, and partner with a National Genetics Advisory Board to establish ethical procedures for the collection and use of biological samples, as well as the dissemination of genetic results using a community-based participatory research framework. The design of the BSG Core is based on our experiences and use of the Genetics Core in phase I of the CANHR study, and on the stated health priorities of our community partners and Tribal Elders.