CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 本修订申请(A2)响应了CTSA为临床和转化研究建立和维持学术-社区合作伙伴关系的倡议/为了实现这一目标，我们创建了临床和转化研究研究所(ICTR)，该研究所建立在成功的相互依存的计划基础上，包括儿科和成人患者研究设施、核心实验室、K30临床研究培训计划，扩大到包括博士临床研究，以及NCRR K12职业发展奖。卢旺达问题国际法庭由阿尔伯特·爱因斯坦医学院、耶希瓦大学和蒙特菲奥里医学中心共同支持，并积极与布朗克斯140万族裔人口组成的社区接触。卢旺达问题国际法庭还与区域和附属机构合作，包括纽约市卫生局、北布朗克斯卫生网、临床主任网、雷曼学院和新罗谢尔护理学院，以扩大整个布朗克斯的研究和培训机会。CTSA在过去两年的发展过程中，通过这些变革性的合作伙伴关系，吸引了来自多个学科(包括医学、牙科、护理、流行病学、社会工作和生物医学科学)的广泛教师。在制定爱因斯坦2007年战略研究计划的同时，我们1)评估了机构内部的障碍，以培养内在的协同作用；2)启动了机构范围内建立跨学科研究联系的进程；3)制定了巩固支持临床/转化研究的现有基础设施的计划；4)投资于新的基础设施--包括有形设施和项目，以支持CTSA任务；5)统一IRB审查程序；6)强调培训和培养一批年轻的研究人员。这个新研究所的合作伙伴共同提供有形资源，包括一个新的200,000 NSF遗传和转化医学中心，30,000 NSF空间，用于卢旺达问题国际法庭的方案和调查人员，一个联合临床研究捐赠基金，以及支持翻译技术和学者的配套资金。卢旺达问题国际法庭的组成部分是：a)研究教育、培训和职业发展；b)设计、生物统计和研究伦理资源；c)参与者和临床互动资源，包括成人和儿科研究单位；d)社区参与和协作；e)监管知识和支持；f)生物医学信息学；g)开发；新的临床/翻译方法“孵化器”(干细胞研究、生物统计学方法、行为/社会科学研究和表观基因组学研究)；h)翻译技术和资源(MS分析核心、生物库、生物标记化验核心、翻译遗传学和基因组资源、细胞治疗实验室)；i)试点和合作项目；和j)其他关键要素(共享设施和核心，以及跨学科研究方案)。卢旺达问题国际法庭的使命是通过促进多学科合作，解决研究中的翻译“障碍”，提供基础设施和协作支持，以及加强培训、教育和职业发展，加强临床和转化性研究。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This revised application (A2) responds to the CTSA initiative to establish and sustain an academic-community partnership for clinical and translational research/To achieve this goal, we created the Institute for Clinical and Translational Research (ICTR) founded on successful inter-dependent programs, including pediatric and adult patient research facilities, core laboratories, a K30 clinical research training program expanded to include a PhD n clinical investigation, and an NCRR K12 award for Career Development. The ICTR is jointly supported by the Albert Einstein College of Medicine, Yeshiva University and Montefiore Medical Center, and actively engages the communities comprising the 1.4 million ethnically diverse population of the Bronx. The ICTR also collaborates with regional and affiliated institutions, including the NYC Department of Health, the North Bronx Health Network, the Clinical Directors Network, Lehman College, and New Rochelle College of Nursing to expand research and training opportunities across the Bronx. The CTSA development process over the past 2 years has engaged a broad array of faculty from a number of disciplines (including medicine, dentistry, nursing, epidemiology, social work, and biomedical sciences) through these transformative partnerships. In parallel with developing Einstein's 2007 Strategic Research Plan, we 1) assessed the barriers within our institutions to cultivate inherent synergies; 2) initiated an Institution-wide process of forging interdisciplinary research linkages; 3) developed plans to consolidate existing infrastructure that supports clinical/translational research; 4) invested in new infrastructure- both physical facilities and programsthat support the CTSA mission; 5) unified the IRB review process; and 6) emphasized the training and nurturing a cohort of young investigators. The partners in this new Institute jointly provide tangible resources, including a new 200,000 nsf Center for Genetic and Translational Medicine, 30,000 nsf of space for ICTR programs and investigators, a joint Clinical Research Endowment fund, and matching funds to support translational technologies and scholars. The ICTR components are: a) Research Education, Training, and Career Development; b) Design, Biostatistics, and Research Ethics Resource; c) Participant and Clinical r Interaction Resources, including Adult and Pediatric Research Units; d) Community Engagement and Collaboration; e) Regulatory Knowledge and Support; f) Biomedical Informatics; g) Development; Novel Clinical/Translational Methodology "incubators" (Stem Cell Research, Biostatistical Methodologies, Behavioral/Social Science Research, and Epigenomics Research); h) Translational Technologies and Resources (MS Analytic Core, Biorepository, Biomarker Assay Core, Translational Genetics and Genomics Resource, and Cellular Therapeutics Laboratory); i) Pilot & Collaborative Projects; and j) Other key elements (shared facilities and cores, and transdisciplinary research programs). The mission of the ICTR is to enhance clinical and translational research by promoting multidisciplinary collaboration, addressing translational 'blocks' in research, providing infrastructure and collaborative support, and enhancing training, education, and career development.