Elekta Neuromag Electronics Upgrade

描述(申请人提供)：脑磁图(MEG)和脑电图(EEG)是唯一的非侵入性人脑成像方法，直接测量神经电流，从而提供精确的时间分辨率，能够检测和精确计时大脑活动的瞬时变化，以及研究大脑区域之间的动态相互作用。对于多通道脑磁图和脑电记录，在最好的情况下，可以以低于1厘米的精度定位测量背后的来源。最近，人们对研究与正常脑功能相关的微弱高频振荡以及与侵入性记录中观察到的异常癫痫事件有关的快速信号越来越感兴趣。此外，已经证明，在适当的条件下，检测大脑皮质内外深部区域的活动是可行的。对于所有这些研究，良好的幅度分辨率和快速采样率是先决条件。由于其非常实时的性质，脑磁图和脑电信号非常适合于涉及脑活动特征的实时处理的应用，例如脑机接口(BMI)和实验，其中呈现的刺激由大脑状态控制。为了能够检测低幅度和/或高频信号并进行实时数据处理，我们建议对马萨诸塞州综合医院(MGH)马蒂诺斯中心的全头MEG/EEG电子设备进行升级，这是新英格兰地区唯一最先进的MEG设备。新的电子设备将提供更高的采样率(高达8千样本/S，而不是现在的3千样本/S)，比目前的电子设备更高的幅度分辨率(24位而不是16位)。目前的电子设备是在90年代末开发的，于2001年安装了该系统。此外，新的现代脑磁图/脑电电子设备将允许在BMI和其他实时应用程序的记录过程中直接访问数据。波士顿地区的许多研究小组都在使用MGH MEG/EEG系统，所有这些研究小组都将直接受益于拟议的升级。此外，我们的临床脑磁图服务为当地和地区医院的患者提供癫痫活动的多模式成像和术前功能图。

DESCRIPTION (provided by applicant): Magnetoencephalography (MEG) and electroencephalography (EEG) are the only non-invasive human brain imaging methods measuring neural currents directly thus providing exquisite temporal resolution and allowing detection and precise timing of transient changes in brain activity as well as studies of dynamic interactions between brain regions. With multichannel MEG and EEG recordings it is possible to locate the sources underlying the measurements in best cases with an accuracy of less than 1 cm. Recently, there has been increasing interest in studying weak high-frequency oscillations associated with normal brain function as well as fast signals related to abnormal epileptic events, observed in invasive recordings. Furthermore, it has been demonstrated that under suitable conditions it is feasible to detect activity from deep brain areas on and outside the cortex. For all these studies a fine amplitude resolution and fast sampling rates are a prerequisite. Due to their very real-time nature, MEG and EEG signals are very suitable for applications involving real-time processing of signatures of brain activity such as brain-machine interfaces (BMI) and experiments in which the stimuli presented are controlled by the "brain state". To enable detection of low-amplitude and/or high- frequency signals and real-time data processing, we propose an upgrade to the electronics of the whole-head MEG/EEG at the Martinos Center of Massachusetts General Hospital (MGH), the only state-of-the-art MEG installation in New England area. The new electronics will provide higher sampling rates (up to 8 ksamples/s instead of present 3 ksamples/s), higher amplitude resolution (24 bits instead of 16 bits) than the present electronics, developed in the late 90s and installed with the system in 2001. In addition, the new modern MEG/EEG electronics will allow direct access to the data during recordings for BMI and other real-time applications. The MGH MEG/EEG system is used by a multitude of research groups in the Boston area, all of which will directly benefit from the proposed upgrade. In addition, our clinical MEG service provides multimodal imaging of epileptic activity and presurgical functional mapping for patients from local and regional hospitals.