LTQ-Orbitrap Mass Spectrometer.

描述（由申请人提供）：纽约大学神经科学质谱核心设施，100位对冲基金临床蛋白质组学女性设施和纽约大学医学院Skirball研究所Kimmel分子生物医学中心内的纽约大学蛋白质分析设施致力于确保生物医学科学家能够使用尖端的质谱技术来进行他们的研究。我们正在申请一个热电子LTQ-Orbitrap Velos质谱仪的资金，以便为11个nih资助的主要用户和5个次要用户提供准确、灵敏的检测、鉴定、表征和相对定量涉及许多重要疾病的蛋白质和肽。此外，所要求的仪器将能够进行稳定同位素标记（SILAC）实验，用于研究神经元和其他细胞的细胞内信号转导。这些实验将大大增加我们对许多神经退行性、发育性、传染性和神经肌肉疾病和癌症的原因和机制的理解。

DESCRIPTION (provided by applicant): The NYU Mass Spectrometry Core Facility for Neuroscience, the 100 Women in Hedge Funds Clinical Proteomics Facility and the NYU Protein Analysis Facility within the Kimmel Center for Molecular Biomedicine at the Skirball Institute at the NYU School of Medicine are dedicated to ensuring that biomedical scientists have access to cutting edge mass spectrometry technology to enable their research. We are requesting funds for a Thermo Electron LTQ-Orbitrap Velos mass spectrometer to make possible the accurate and sensitive detection, identification, characterization and relative quantitation of proteins and peptides involved in many important diseases for 11 NIH-funded major users and 5 minor users. In addition, the requested instrument would enable stable isotope labeling (SILAC) experiments for the study of intracellular signal transduction in neurons and other cells. These experiments would greatly increase our understanding of the causes and mechanisms of a number of neurodegenerative, developmental, infectious, and neuromuscular diseases and cancer.