Emory Parkinson's Disease Collaborative Environmental Research Center

埃默里·帕金森病协同环境研究中心(PD-CERC)。 在埃默里大学帕金森氏病研究合作中心过去的成功基础上，我们提出了一个整合和合作的中心，旨在了解环境毒物，如杀虫剂，如何促进阿尔金森病的发病机制。在过去的几年里，我们的研究小组已经确定了似乎与帕金森病的发生和发展有关的关键机制，特别是那些由环境因素引发的机制。我们中心的目标是更好地了解环境毒物如何扰乱黑质中的多巴胺稳态、线粒体功能和氧化还原平衡，以及受影响的神经元如何对这些侮辱做出反应。由于这些扰动中的许多并不局限于黑质纹状体多巴胺系统甚至大脑，因此利用新的代谢组学方法在燕麦血清中识别这些过程的外周生物标志物是一个令人兴奋的机会。该中心的总体主题是，环境毒物，如杀虫剂，通过特定的分子靶标作用于破坏氧化还原状态；正是神经元固有的抵御这些变化的能力决定了受帕金森氏病影响的神经元是存活还是死亡。PD-CERC有五个主要目标：1. 确定环境和遗传对多巴胺储存的破坏如何导致氧化 2.确定多巴胺神经元对线粒体功能障碍和氧化应激反应的新机制，3.确定环境毒物如何破坏细胞和外周脑室的氧化还原平衡，4.确定环境毒物和特发性帕金森病的新代谢生物标志物，5.通过招募研究人员、刺激新想法、促进新项目和为年轻研究人员提供职业发展来丰富该中心，6.整合线粒体功能障碍、多巴胺代谢和氧化应激的信息，以指导未来预防、诊断和治疗帕金森病的策略。这些目标的完成将提高我们对环境毒物如何增加帕金森病风险的理解，并将为量身定做旨在减轻帕金森病环境暴露不良影响的治疗干预措施奠定基础。

Emory Parkinson's Disease Collaborative Environmental Research Center (PD-CERC). Building upon the past successes of the Emory University Collaborative Center for Parkinson's Disease Research, we propose an integrated and collaborative center that is aimed at understanding how environmental toxicants, such as pesticides, contribute to the pathogenesis of arkinson's disease. Over the past several years our research groups have identified key mechanisms that appear to be involved in the onset and progression of PD, especially those triggered by environmental factors. The goal of our center is to better understand how environmental toxicants disrupt dopamine homeostasis, mitochondrial function, and redox balance n the substantia nigra, and how the affected neurons respond to these insults. Since many of these perturbations are not restricted to the nigrostriatal dopamine system or even the brain, there is an exciting opportunity to identify peripheral biomarkers of these processes in the serum of oatients using novel metabolomic methods. The overall theme of the center is that environmental toxicants, such as pesticides, act through specific molecular targets to disrupt redox state; and it is the inherent ability of the neurons to defend against these changes that dictate whether the neurons affected in Parkinson's disease survive or die. The PD-CERC has five major objectives: 1. to determine how environmental and genetic disruption of dopamine storage leads to oxidative damage, 2. to identify novel mechanisms by which the dopamine neurons respond to mitochondrial dysfunction and oxidative stress, 3. to determine how environmental toxicants disrupt redox balance in cellular and peripheral compartments, 4. to identify novel metabolomic biomarkers of environmental toxicants and idiopathic PD, 5. to enrich the center through recruitment of investigators, stimulation of new ideas, fostering of new projects, and by providing career development to young investigators and 6. To integrate information on mitochondrial dysfunction, dopamine metabolism, and oxidative stress to guide future strategies for the prevention, diagnosis, and treatment of PD. Completion of these objectives will improve our understanding of how environmental toxicants increase the risk of PD and it will lay the foundation for tailoring therapeutic interventions aimed at mitigating the adverse effects of environmental exposures in PD.