HEMISPHERIC SPECIALIZATION AND COMMUNICATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 今年，我们实验室的研究重点是开发和实施一种新的软件程序，允许从磁共振图像中自动提取皮质沟。然后，可以在多个维度上对这些灰质进行量化，包括表面积、平均和最大深度、灰质厚度和褶皱开口。 我们最初的研究是在84只黑猩猩身上进行的，我们发现许多沟在种群水平上存在显著的不对称性，特别是西尔维安沟和额眶沟，这些沟是用来描绘布罗卡区和韦尼克区的地标。我们进一步发现，黑猩猩额叶沟的体积和不对称性的变化与口面部运动控制的行为测量有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This year, studies in our laboratory focused on the development and implementation of a novel software program that allows for the automated extraction of cortical sulci from magnetic resonance images. The sucli can then be quantified on a number of dimensions including surface area, mean and maximum depth, grey matter thickness and fold opening. Our initial studies were conducted in a sample of 84 chimpanzees and we found significant population-level asymmetries for a number of sulci, notably the sylvian fissure and fronto-orbital sulcus, sulci that are landmarks used to delineate Broca's and Wernicke's areas. We further found that variation in the volumes and asymmetries of the frontal lobe sulci were associated with behavioral measures of oro-facial motor control in the chimpanzees.