SWAN Repository III

描述（由申请人提供）：本竞争性续期申请旨在提供与SWAN储存库相关的血清、血浆、尿液、DNA和转化细胞的持续维护和活动，这些储存库来自5个种族的3302名妇女，这些妇女在绝经前、绝经期间和绝经后每年进行评估。这些资料库是全国妇女健康研究（SWAN）的一个部门，旨在支持、促进和扩展核心SWAN；此外，储存库还提供了一种向更大的科学界开放SWAN资源的机制。实施与这一竞争性更新的三个拟议具体目标相关的活动将：1)继续管理目前的170万储存库标本以及2009年至2014年SWAN IV野外部署后将积累的额外标本；2)扩展DNA库，这是由于我们在细胞永生方面的投资，最常被要求的唯一可再生的标本类型；3)透过发展一个两级的网上“数据仓库”，促进有关SWAN研究、其数据及资料库资源的有效资讯交换；4)对标本利用的申请审核流程进行持续管理，对包括《材料转让协议》在内的标本分发进行行政管理；5)制定促进标本利用的策略；6)扩大与SWAN研究及其资源库相关的遗传学研究范围。

DESCRIPTION (provided by applicant): This competing renewal application is to provide for ontinued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), are meant to support, facilitate and extend the Core SWAN; additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014; 2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization; 3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based "data warehouse"; 4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements; 5) engage in strategies to promote utilization of specimens; and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.