Emotion Regulation in Children of Parents with Bipolar Disorder

描述（由申请人提供）：这项NIMH指导患者导向研究职业发展（K-23）奖申请的目的是支持我的长期职业目标，即整合创新的神经成像技术和情绪调节机制，以了解双相情感障碍（BD）的神经发育。我之前的培训是对有家族性双相障碍风险的儿童进行现象学和磁共振成像（MRI）形态计量学分析。以前对双相障碍后代的神经影像学研究的一个局限性是，对这一弱势群体中情绪调节的潜在潜在机制评估不足，不考虑与疾病发作相关的混杂因素，如共同发生的精神疾病、药物暴露和物质使用。因此，为了实现我的职业目标，即最大限度地将体内神经成像技术应用于高危临床人群，我建议通过参加课程作业、教学阅读、指导、学习、学习、学习，来获得整合儿童情绪调节和失调调查、功能（fMRI）、磁共振波谱（MRS）、统计分析和研究伦理行为的专业知识。和体验式学习活动，以补充拟议的研究活动。双相障碍是一种普遍的、终生的、进行性疾病，通常开始于青春期或成年早期。双相障碍的一个主要症状是情绪失调。大脑和小脑区域，包括前额叶皮质、腹侧纹状体、杏仁核、海马体和小脑蚓部，已经被证明可以调节患有双相障碍的儿童和青少年的情绪过程，以及家族性双相障碍的风险。我的短期目标是应用功能磁共振成像和MRS，结合情感神经科学中使用的奖励和信息处理范式。阐明具有家族性双相障碍风险的青春期前儿童情绪调节的功能和神经化学基础。本项目获得的数据将为未来的纵向研究提供信息，以促进我们对涉及该疾病发展的风险和保护因素的理解。拟议的综合研究和培训计划，加上斯坦福大学强大的研究环境，将使我成为BD神经发育领域的独立研究者。

DESCRIPTION (provided by applicant): The purpose of this NIMH Mentored Patient-Oriented Research Career Development (K-23) Award application is to support my long-term career objective of integrating innovative neuroimaging techniques and mechanisms of emotion regulation to understand the neurodevelopment of Bipolar Disorder (BD). My previous training is in the phenomenology and Magnetic Resonance Imaging (MRI) morphometric analyses of children at familial risk for developing BD. One limitation of previous neuroimaging studies in bipolar offspring is the inadequate assessment of the potential underlying mechanisms of emotion regulation in this vulnerable cohort, independent of confounds associated with illness onset, such as co-occurring psychiatric conditions, medication exposure, and substance use. Therefore, to achieve my career goal of maximizing the application of in vivo neuroimaging techniques to at-risk clinical populations, I propose to gain expertise integrating pediatric investigations of emotion regulation and dysregulation, functional (fMRI), magnetic resonance spectroscopy (MRS), statistical analyses, and the ethical conduct of research by participating in course work, didactic readings, mentoring, and experiential learning activities that complement the proposed research activities. BD is a prevalent, life-long, progressive disease that typically begins in adolescence or early adulthood. A cardinal symptom of BD is emotion dysregulation. Brain and cerebellar regions, including the prefrontal cortex, ventral striatum, amygdala, hippocampus, and cerebellar vermis have been shown to modulate emotional processes in children and adolescents with, and at familial risk for, BD. My short-term goal is to apply fMRI and MRS, in conjunction with reward and information-processing paradigms used in affective neuroscience, to elucidate the functional and neurochemical bases for emotion regulation in preadolescent children at familial risk for developing BD. Data obtained in this project will inform future longitudinal studies to facilitate the advancement of our understanding of risk and protective factors that are involved in the development of this illness. The proposed integrated research and training programs, together with the strong research environment of Stanford University, will foster my development into an independent investigator in the field of the neurodevelopment of BD.