The University of Rochester Core Center for Musculoskeletal Biology and Medicine

这项名为“罗切斯特大学肌肉骨骼生物学和医学核心中心（URCCMBM）”的P30申请旨在为罗切斯特大学建立的、NlH资助的研究人员提供共享设施和服务，他们正在解决肌肉骨骼生物学和医学方面的科学问题，以提高效率，加快研究步伐，促进临床转化。此外，通过其独特的旨在扩大研究基地的充实计划，URCCMBM旨在促进肌肉骨骼研究中心（CMSR）的研究助理教授（RAP）和未资助的医师科学家（UPS）的发展和推广，由于最近基金会资助，公司赞助的研究和大学启动包对他们的职业发展至关重要，他们的外部资金选择有限。在URCCMBM中提出了三个核心。行政核心将监督整个计划，并运行充实计划，其中包括：试点项目（针对RAP和UPS）、指导子核心、临床研究子核心、访问教授计划、旅行补助金和年度研究研讨会。组织学、生物化学和分子成像核心将促进体外转化研究（细胞和分子分析、组织学和形态测量学），生物力学和全组织成像核心将促进体内转化研究（力学测试、微ct、体内多光谱和超声成像）。URCCMBM得到了医学和牙科学院以及NIH资助的CTSI的大力支持。执行委员会将每半年审查一次该计划，以确保URCCBMB实现其主要目标：提高研究效率，促进合作，从而获得新的NIH拨款，以及我们的RAP和UPS的职业发展。

This P30 application, entitled "The University of Rochester Core Center for Musculoskeletal Biology and Medicine (URCCMBM)," seeks to provide shared facilities and services to the well-established, NlH funded Investigators at the University of Rochester who are addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation. Additionally, through its unique Enrichment Program designed to expand the research base, the URCCMBM aims to facilitate the development and promotion of Research Assistant Professors (RAP) and unfunded physician-scientists (UPS) in the Center for Musculoskeletal Research (CMSR), who have limited options for extramural funding given the recent disappearance of Foundation grants, corporate-sponsored research and University start-up packages that are critical for their career advancement. Three Cores are proposed within the URCCMBM. The Administrative Core will oversee the entire program and run the Enrichment Program that includes: Pilot Projects (targeted to RAP & UPS), a Mentoring sub-Core, a Clinical Research sub-Core, a Visiting Professor Program, Travel Grants and an Annual Research Symposium. The Histology, Biochemistry and Molecular Imaging Core will facilitate in vitro-translational research (cellular and molecular assays, histology and morphometry), and the Biomechanics and Whole Tissue Imaging Core will facilitate in vivo translational research (mechanical testing, micro-CT, in vivo multispectral and ultrasound imaging). The URCCMBM is heavily leveraged by institutional support from the School of Medicine & Dentistry and the NIH funded CTSI. The Executive Committee will review the program semiannually to ensure that URCCBMB achieves its primary goals of: improved research efficiency, fostered collaborations leading to new NIH grants, and career advancement of our RAP and UPS.