CLINICAL TRIAL: FAMILY THERAPY AND FLUOXETINE IN THE TREATMENT OF ADOLESCENT ANO

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 在一项具有充分把握度的随机对照试验中，比较行为家庭疗法（BFT）和系统家庭疗法（SFT）（两种理论上和程序上不同的治疗方法）的相对短期和长期有效性，以及氟西汀与安慰剂相比对青少年神经性厌食症（AN）的累加效应。我们期望BFT在维持门诊病人正常体重和营养方面优于SFT上级。然而，许多人仍会出现症状。我们预计氟西汀在减少两个家庭治疗（FT）组中焦虑、强迫症和进食障碍（艾德）特异性症状方面上级安慰剂。最后，由于正常化营养可能对氟西汀应答至关重要，我们预期BFT +氟西汀组的总体应答和结局最佳。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Compare the relative short and long term effectiveness of behavioral family therapy (BFT) and systems family therapy (SFT), two theoretically and procedurally distinct treatments, and the additive effects of fluoxetine compared to placebo for adolescent anorexia nervosa (AN) in an adequately powered randomized controlled trial. We expect BFT to be superior to SFT in maintaining normal weight and nutrition as outpatients. However, many individuals will remain symptomatic. We expect fluoxetine to be superior to placebo in terms of reducing anxiety, obsessionality, and eating disorder (ED) specific symptoms in both family therapy (FT) groups. Finally, because normalized nutrition may be critical for fluoxetine response, we would expect the BFT + fluoxetine group to have the best overall response and outcome.