CENTER OF EXCELLENCE IN DIABETES AND OBESITY RESEARCH: CORE E

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心血管成像和功能核心的作用是支持COBRE项目和相关研究，检查糖尿病和肥胖对心血管功能的影响。所提供的服务包括超声心动图成像、血压和心率的尾袖测量以及左心室（LV）压力-容积测量。高容量超声心动图目前使用Philips（HP）Sonos 5500机器进行，该机器连接到配有回波分析软件的ComPACS计算机工作站。所有测量和计算数据均自动存储在ComPACS <$DE或SQL数据库中，采用DICOM SR格式，链接到Crystal Reports，用于生成自定义输出文档。用CODA-6尾套系统（肯特科技公司（Kent Scientific））对清醒小鼠的血压和心率进行非侵入性测量。使用Millar压力容积传导系统（MPCU-200）对小鼠进行主动脉和LV导管插入术。使用Chart（ADInstruments）获取血液动力学数据，并使用PVAN软件（Millar）分析以生成收缩和舒张指数。核心不仅为COBRE项目提供程序和技术支持，而且还扩展了新研究人员的能力，因为他们正在进行和未来的研究项目需要心血管成像。因此，核心方案促进了该方案支助的调查人员的职业发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The role of the Cardiovascular Imaging and Function Core is to support the COBRE Projects and related investigations examining the effects of diabetes and obesity on cardiovascular performance. The services provided include echocardiographic imaging, tail-cuff measurement of blood pressure and heart rate, and left ventricular (LV) pressure-volume measurement. High-volume echocardiography is currently performed with Philips (HP) Sonos 5500 machine coupled to a ComPACS Computer WorkStation complete with Echo Analysis Software. All measurements and computed data are automatically stored in ComPACS MSDE or SQL database in DICOM SR format linked to Crystal Reports for generating customized output documents. Non-invasive measurement of blood pressure and heart rate in conscious mice is performed with a CODA-6 tail-cuff system (Kent Scientific). Aortic and LV catheterization is performed using a Millar pressure volume conductance system (MPCU-200) for mice. Hemodynamic data are acquired using Chart (ADInstruments) and analyzed using PVAN software (Millar) to generate indexes of contraction and relaxation. The Core not only provides procedural and technological support for the COBRE Projects, but also extends the capabilities of new investigators as they embark on ongoing and future research projects requiring cardiovascular imaging. Thus, the Core advances the career development of COBRE-supported investigators.