Mentoring a Cancer Genetics Program

描述（由申请人提供）：本COBRE更新申请的目的是继续发展有前途的初级研究人员在癌症遗传学的研究事业，并建立在这一领域的核心方案实力。职业发展将利用一个强大的核心研究导师谁将提供职业发展的建议，以及科学发展和实验室管理健全的实用建议。这个COBRE中的五个项目集中在几个重叠的主题上，这些主题有助于我们理解遗传不稳定性，细胞炎症以及细胞对这些因素的反应。除了一个项目外，所有项目都特别关注研究癌症的小鼠模型，所有项目都具有高度的翻译相关性。一个由COBRE的导师和核心董事组成的内部咨询委员会都坚定地致力于该计划，并有出色的研究和指导记录。此外，一个杰出的外部顾问委员会将参与指导和评估初级研究人员和COBRE计划本身的进展。职业发展将涉及一系列的计划会议，接触教学补助金写作会议，和研讨会，以开发一个高度协作的环境，为初级教师，以及路易斯安那州癌症研究联盟（LCRC）的其他成员。COBRE还为我们的科学家提供了出色的核心设施开发，使他们能够进行新的实验。LCRC为涉及杜兰大学，LSU健康科学中心和泽维尔大学的癌症研究提供了杰出的跨学科和机构间环境。LCRC由长期的州烟草税资助，其明确目标是竞争NCI指定为新奥尔良的癌症中心。在未来数年，该公司将提供出色的招聘、一座专为该公司而设的新大楼，以及一系列运作良好的核心设施。这个COBRE代表了LCRC的核心，为我们在卡特里娜飓风后的重建做出了巨大贡献，并提供了有助于指导整个LCRC的指导和发展的框架。 公共卫生相关性（由申请人提供）：这个眼镜蛇一直负责我们的一些年轻教师获得他们的第一个NIH R0I资金的成功，我们相信我们准备在更新更多的增长。这将大大提高路易斯安那州东南部的研究资金基础和指导人才库。此外，这里描述的科学计划和核心提供了旨在对抗癌症的杰出和高度转化的项目。

DESCRIPTION (provided by applicant): The objective of this COBRE renewal application is to continue to develop the research careers of promising junior investigators In Cancer Genetics and to build core Programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and lab management. The five projects in this COBRE focus one several overlapping themes that contribute to our understanding of genetic instability, cellular inflammation, and the cell's responses to these factors. All but one of the proposals specifically focus on mouse models for studying cancer, and all projects have a high translational relevance. An internal advisory committee composed of mentors and core directors for this COBRE are all strongly committed to the program, and have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Louisiana Cancer Research Consortium (LCRC). The COBRE also provides outstanding core facility development for our scientists to make new experiments available to them. The LCRC provides an outstanding interdisciplinary and inter-institutional environment for cancer research involving Tulane University, LSU Health Sciences Center and Xavier University. The LCRC is funded by a long-term state tobacco tax with the express goal of competing for NCI designation as a cancer center in New Orleans. The LCRC provides outstanding recruitment in the next few years, a new building dedicated to the LCRC and a series of well-operated core facilities. This COBRE represents the centerpiece of the LCRC and contributed strongly to our rebuilding post-Katrina as well as providing the framework that helps guide mentoring and development throughout the LCRC. PUBLIC HEALTH RELEVANCE (provided by applicant): This COBRE has been responsible for the success of a number of our young faculty obtaining their first NIH R0I funding and we believe we are poised for even more growth in the renewal. This will greatly enhance the research funding base and mentoring pool in Southeastern Louisiana. In addition, the scientific programs and cores described here provide outstanding and highly translational projects aimed at combating cancer.