Mentoring a Cancer Genetics Program

指导癌症遗传学项目

• 批准号: 8517770
• 负责人: Prescott L. Deininger
• 金额: $ 208.42万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8517770
• 关键词: Achievement; Advisory Committees; Area; Basic Science; Cancer Center; Cells; Centers of Research Excellence; Clinical Research; Collaborations; Commit; Communities; Core Facility; Development; Environment; Evaluation; Exposure to; Faculty; Fostering; Funding; Genetic; Genetic Programming; Goals; Grant; Growth; Guidelines; Health Sciences; Hurricane; Inflammation; Institutes; Louisiana; Malignant Neoplasms; Mentors; NCI-Designated Cancer Center; National Cancer Institute; Peer Review; Pilot Projects; Play; Policies; Positioning Attribute; Records; Recruitment Activity; Regional Cancer; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Scientist; Senior Scientist; Series; Services; Source; Structure; Taxes; Tobacco; Translational Research; United States National Institutes of Health; Universities; Update; Writing; anticancer research; base; cancer genetics; cancer research center director; career; career development; combat; expectation; improved; interest; meetings; member; mouse model; multidisciplinary; programs; rapid growth; research study; response; sound; success

The objective of this COBRE renewal application is to continue to develop the research careers of promising junior investigators In Cancer Genetics and to build core Programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and lab management. The five projects in this COBRE focus one several overlapping themes that contribute to our understanding of genetic instability, cellular inflammation, and the cell's responses to these factors. All but one of the proposals specifically focus on mouse models for studying cancer, and all projects have a high translational relevance. An internal advisory committee composed of mentors and core directors for this COBRE are all strongly committed to the program, and have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Louisiana Cancer Research Consortium (LCRC). The COBRE also provides outstanding core facility development for our scientists to make new experiments available to them. The LCRC provides an outstanding interdisiplinary and interinstitutional environment for cancer research involving Tulane Univerisy, LSU Heath Sciences Center and Xavier University. The LCRC is funded by a long-term state tobacco tax with the express goal of competing for NCI designation as a cancer center in New Orleans. The LCRC provides outstanding recruitment in the next few years, a new building dedicated to the LCRC and a series of well-operated core facilities. This COBRE represents the centerpiece of the LCRC and contributed strongly to our rebuilding post-Katrina as well as providing the framework that helps guide mentoring and development throughout the LCRC.

COBRE更新申请的目的是继续发展癌症遗传学中有前途的初级研究人员的研究事业，并在这一领域建立核心的程序优势。职业发展将利用一个强大的核心研究导师谁将提供职业发展的建议，以及科学发展和实验室管理健全的实用建议。这个COBRE中的五个项目集中在几个重叠的主题上，这些主题有助于我们理解遗传不稳定性，细胞炎症以及细胞对这些因素的反应。除了一个项目外，所有项目都特别关注研究癌症的小鼠模型，所有项目都具有高度的翻译相关性。一个由COBRE的导师和核心董事组成的内部咨询委员会都坚定地致力于该计划，并有出色的研究和指导记录。此外，一个杰出的外部顾问委员会将参与指导和评估初级研究人员和COBRE计划本身的进展。职业发展将涉及一系列的计划会议，接触教学补助金写作会议，和研讨会，以开发一个高度协作的环境，为初级教师，以及路易斯安那州癌症研究联盟（LCRC）的其他成员。COBRE还为我们的科学家提供了出色的核心设施开发，使他们能够进行新的实验。LCRC为癌症研究提供了一个优秀的跨学科和跨机构的环境，涉及杜兰大学，路易斯安那州立大学健康科学中心和泽维尔大学。LCRC由长期的州烟草税资助，其明确目标是竞争NCI指定为新奥尔良的癌症中心。在未来数年，该公司将提供出色的招聘、一座专为该公司而设的新大楼，以及一系列运作良好的核心设施。这个COBRE代表了LCRC的核心，为我们在卡特里娜飓风后的重建做出了巨大贡献，并提供了有助于指导整个LCRC的指导和发展的框架。

项目成果

Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription.

• DOI: 10.1080/15592294.2018.1445900
• 发表时间: 2018
• 期刊: Epigenetics
• 影响因子: 3.7
• 作者: Baribault C;Ehrlich KC;Ponnaluri VKC;Pradhan S;Lacey M;Ehrlich M
• 通讯作者: Ehrlich M

Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood.

• DOI: 10.2217/epi.15.104
• 发表时间: 2016-01
• 期刊: Epigenomics
• 影响因子: 3.8
• 作者: Buckley L;Lacey M;Ehrlich M
• 通讯作者: Ehrlich M

Genetic and epigenetic alterations of steroidogenic factor‑1 in ovarian tumors.

• DOI: 10.3892/ijo.2012.1758
• 发表时间: 2013-02
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Miller S;Bhasin N;Urrego H;Moroz K;Rowan BG;Ramayya MS;Makridakis NM
• 通讯作者: Makridakis NM

Analysis of EBV Transcription Using High-Throughput RNA Sequencing.

使用高通量 RNA 测序分析 EBV 转录。

• DOI: 10.1007/978-1-4939-6655-4_7
• 发表时间: 2017
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: O'Grady,Tina;Baddoo,Melody;Flemington,ErikK
• 通讯作者: Flemington,ErikK

Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci.

• DOI: 10.1093/nar/gku687
• 发表时间: 2014
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Kines KJ;Sokolowski M;deHaro DL;Christian CM;Belancio VP
• 通讯作者: Belancio VP