Cancer Imaging

癌症成像和早期检测计划的目标是促进癌症研究、诊断和 通过使用多模式解剖和分子成像(MI)进行新研究的管理 战略。这一目标将通过多模式成像的开发和应用来实现 揭示疾病的分子基础、开发多参数诊断工具和 推进癌症的有效治疗。该项目由来自七个专业的研究人员组成 领域：成像仪器/工程；建模/生物统计学；化学；分子成像； 癌症生物学/蛋白质组学；小鼠模型/小动物成像在癌症治疗中的应用；以及 临床肿瘤学。计划成员的研究产生了新的成像工具和新的 对癌症生物学的洞察和对治疗的反应。这些令人兴奋的发现包括新的方法 肿瘤基因治疗；免疫细胞转运和有效免疫治疗的成像；下一代 用于成像细胞凋亡/血管生成的探针；创新的内窥镜光学成像 策略；用于体外诊断的蛋白质组纳米传感器；小动物仪器的进展 成像；以及临床癌症成像策略的翻译。该计划在#年的显著扩展 这最后两年是持续增长的基础，部分原因是增加了一个新的 癌症早期检测中心，该中心汇集了专注于体外和体内研究的科学家 诊断。该计划通过将生物学家、化学家、工程师、 放射科医生、计算科学家以及临床和翻译研究人员共同解决难题 影像方面的问题，并解决肿瘤学中未得到满足的需求。43名项目成员来自12个国家 医学院、工程学院和人文与科学学院。会员是主要的 参加了一个P50项目、四个U54项目和两个NCI T32资助的博士后培训 资助金。这些成员还积极与全国各地的其他癌症中心接触，包括 弗雷德·哈钦森癌症研究中心，并正在扩展到涉及其他中心的临床试验 美国(例如南非和印度)。领导层在项目开发的目标上团结一致，以 先进的癌症成像技术。该项目目前从NCI获得870万美元的外部资金 以及630万美元的NIH其他研究支持。

The goal of the Cancer Imaging and Early Detection Program is to advance cancer research, diagnosis, and management by carrying out novel research using multimodality anatomical and molecular imaging (MI) strategies. This goal will be achieved through the development and application of multimodality imaging strategies to reveal the molecular basis of disease, to develop multiparametric diagnostic tools and to advance effective treatment for cancer. The program comprises of investigators from seven specialty areas: imaging instrumentation/engineering; modeling/biostatistics; chemistry; molecular imaging; cancer biology/proteomics; mouse models/small animal imaging applications in cancer therapy; and clinical oncology. Research by program members has resulted in both new tools for imaging and new insights in cancer biology and responses to therapy. These exciting findings include new methods to image cancer gene therapy; imaging of immune cell trafficking and effective immunotherapies; next-generation of probes for imaging apoptosis/angiogenesis; innovative endoscopic optical imaging strategies; proteomic nanosensors for in vitro diagnostics; advances in instrumentation for small animal imaging; and translation of clinical cancer imaging strategies. The significant expansion of the program in this last two-year period is the foundation for continued growth, in part, through the addition of a new center for early cancer detection, which brings together scientists focused on both in vitro and in vivo diagnostics. The Program adds value to the Center by bringing biologists, chemists, engineers, radiologists, computational scientists and clinical and translational researchers together to solve the hard problems In imaging and address unmet needs in oncology. The 43 program members come from 12 departments in the Schools of Medicine, Engineering and Humanities & Sciences. Members are major participants in one P50 program project, four U54 projects, and two NCI T32 funded postdoctoral training grants. The members are also actively engaged with other cancer centers around the country including the Fred Hutchinson Cancer Research Center and are extending to clinical trials that involve centers beyond the U.S.A (eg. South Africa and India). The leadership is united in its goals for program development to advance cancer imaging. The program currently receives $8.7 million in extramural funding from the NCI and $6.3 million in other NIH research support.